UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase (EC 2.6.1.91, pglE (gene)) is an enzyme with systematic name UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + 2-oxoglutarate

\rightleftharpoons

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

References

↑ Olivier, N.B.; Chen, M.M.; Behr, J.R.; Imperiali, B. (2006). "In vitro biosynthesis of UDP-N,N′-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry. 45: 13659–13669. doi:10.1021/bi061456h. PMID 17087520.
↑ Schoenhofen, I.C.; McNally, D.J.; Vinogradov, E.; Whitfield, D.; Young, N.M.; Dick, S.; Wakarchuk, W.W.; Brisson, J.R.; Logan, S.M. (2006). "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". J. Biol. Chem. 281: 723–732. doi:10.1074/jbc.m511021200. PMID 16286454.
↑ Rangarajan, E.S.; Ruane, K.M.; Sulea, T.; Watson, D.C.; Proteau, A.; Leclerc, S.; Cygler, M.; Matte, A.; Young, N.M. (2008). "Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni". Biochemistry. 47: 1827–1836. doi:10.1021/bi702032r. PMID 18198901.
↑ Hartley, M.D.; Morrison, M.J.; Aas, F.E.; Borud, B.; Koomey, M.; Imperiali, B. (2011). "Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N′-diacetylbacillosamine". Biochemistry. 50: 4936–4948. doi:10.1021/bi2003372. PMID 21542610.

External links

UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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