UDP-4-amino-4-deoxy-L-arabinose aminotransferase

UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Identifiers
EC number	2.6.1.87
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

UDP-4-amino-4-deoxy-L-arabinose aminotransferase (EC 2.6.1.87, UDP-(beta-L-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase, UDP-Ara4O aminotransferase, UDP-L-Ara4N transaminase) is an enzyme with systematic name UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase.^[1][2] This enzyme catalyses the following chemical reaction

UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate $\rightleftharpoons$ UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

This protein is a pyridoxal 5'-phosphate enzyme.

References

1. Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R. (2003). "Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose". J. Biol. Chem. 278: 24731–24739. doi:10.1074/jbc.m304043200. PMID 12704196.
2. Noland, B.W.; Newman, J.M.; Hendle, J.; Badger, J.; Christopher, J.A.; Tresser, J.; Buchanan, M.D.; Wright, T.A.; Rutter, M.E.; Sanderson, W.E.; Muller-Dieckmann, H.J.; Gajiwala, K.S.; Buchanan, S.G. (2002). "Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme". Structure. 10: 1569–1580. doi:10.1016/s0969-2126(02)00879-1. PMID 12429098.

External links

• UDP-4-amino-4-deoxy-L-arabinose aminotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)