Breast cancer screening

Breast cancer screening
Intervention

A woman having a mammogram

Breast cancer screening is the medical screening of asymptomatic, apparently healthy women for breast cancer in an attempt to achieve an earlier diagnosis. The assumption is that early detection will improve outcomes. A number of screening tests have been employed, including clinical and self breast exams, mammography, genetic screening, ultrasound, and magnetic resonance imaging.

A clinical or self breast exam involves feeling the breast for lumps or other abnormalities. Medical evidence, however, does not support its use in women with a typical risk for breast cancer.[1]

The use of mammography in universal screening for breast cancer is controversial as it may not reduce all-cause mortality and for causing harms through unnecessary treatments and medical procedures. Many national organizations recommend it for most older women. In the United States screening mammography women at normal risk for breast cancer, is only recommended every two years in women between the ages of 50 and 74.[2] Several tools are available to help target breast cancer screening to older women with longer life expectancies.[3] Similar imaging studies can be performed with magnetic resonance imaging but evidence is lacking.[2]

Earlier, more aggressive, and more frequent screening is recommended for women at particularly high risk of developing breast cancer, such as those with a confirmed BRCA mutation, those who have previously had breast cancer, and those with a strong family history of breast and ovarian cancer.

Abnormal findings on screening are further investigated by surgically removing a piece of the suspicious lumps (biopsy) to examine them under the microscope. Ultrasound may be used to guide the biopsy needle during the procedure. Magnetic resonance imaging is used to guide treatment, but is not an established screening method for healthy women.

Breast exam

A pictorial example of breast self-examination in six steps. Steps 1-3 involve visual inspection of the breasts with the arms in different positions. Step 4 is palpation of the breast. Step 5 is palpation of the nipple. Step 6 is palpation of the breast while lying down.

Breast examination (either clinical breast exams (CBE) by a health care provider or by self exams) were once widely recommended. They however are not supported by evidence and may, like mammography and other screening methods that produce false positive results, contribute to harm. The use of screening in women without symptoms and at low risk is thus controversial.[4]

A 2003 Cochrane review found screening by breast self-examination is not associated with lower death rates among women who report performing breast self-examination and does, like other breast cancer screening methods, increase harms, in terms of increased numbers of benign lesions identified and an increased number of biopsies performed.[1] They conclude "at present, breast self-examination cannot be recommended."[1] There was no high quality evidence looking at clinical breast examination.[1]

Mammography

Main article: Mammography

Mammography is a common screening method, since it is relatively fast and widely available in developed countries. Mammography is a type of radiography used on the breasts. It is typically used for two purposes: to aid in the diagnosis of a woman who is experiencing symptoms or has been called back for follow-up views (called diagnostic mammography), and for medical screening of apparently healthy women (called screening mammography).

Mammography is not very useful in finding breast tumors in dense breast tissue characteristic of women under 40 years.[5][6] In women over 50 without dense breasts, breast cancers detected by screening mammography are usually smaller and less aggressive than those detected by patients or doctors as a breast lump. This is because the most aggresnsive breast cancers are found in dense breast tissue, which mammograms perform poorly on.[5]

The presumption was that by detecting the cancer in an earlier stage, women will be more likely to be cured by treatment. This assertion however has been challenged by recent reviews which have found the significance of these net benefits to be lacking for women at average risk of dying from breast cancer.

Mechanism

Normal (left) versus cancerous (right) mammography image.

Screening mammography is usually recommended to women who are most likely to develop breast cancer. In general, this means women who have risk factors such as having a personal or family history of breast cancer or being older women, but not being frail elderly women, who are unlikely to benefit from treatment.

Women who agree to be screened have their breasts X-rayed on a specialized X-ray machine. This exposes the woman's breasts to a small amount of ionizing radiation, which has a very small, but non-zero, chance of causing cancer.

The X-ray image, called a radiograph, is sent to a physician who specializes in interpreting these images, called a radiologist. The image may be on plain photographic film or digital mammography on a computer screen; despite the much higher cost of the digital systems, the two methods are generally considered equally effective. The equipment may use a computer-aided diagnosis (CAD) system.

There is considerable variation in interpreting the images; the same image may be declared normal by one radiologist and suspicious by another. It can be helpful to compare the images to any previously taken images, as changes over time may be significant.

If a suspicious signs are identified in the image, then the woman is usually recalled for a second mammogram, sometimes after waiting six months to see whether the spot is growing, or a biopsy of the breast.[7] Most of these will prove to be false positives, resulting in sometimes debilitating anxiety over nothing. Most women recalled will undergo additional imaging only, without any further intervention. Recall rates are higher in the U.S. than in the UK.[8]

Effectiveness

On balance, screening mammography in older women increases medical treatment and saves a small number of lives.[9] Usually, it has no effect on the outcome of any breast cancer that it detects. Screening targeted towards women with above-average risk produces more benefit than screening of women at average or low risk for breast cancer.

A 2011 Cochrane review estimated that mammography in women between 50 and 75 years old results in a relative decreased risk of death from breast cancer of 15% and an absolute risk reduction of 0.05%. However, when the analysis included only the least biased trials, women who had regular screening mammograms were just as likely to die from all causes, and just as likely to die specifically from breast cancer, as women who did not.[9] The size of effect might be less in real life compared with the results in randomized controlled trials due to factors such as increased self-selection rate among women concerned and increased effectiveness of adjuvant therapies.[10] The Nordic Cochrane Collection (2012) reviews said that advances in diagnosis and treatment might make mammography screening less effective at saving lives today. They concluded that screening is “no longer effective” at preventing deaths and “it therefore no longer seems reasonable to attend” for breast cancer screening at any age, and warn of misleading information on the internet.[11] The review also concluded that "half or more" of cancers detected with mammography would have disappeared spontaneously without treatment. They found that most of the earliest cell changes found by mammography screening (carcinoma in situ) should be left alone because these changes would not have progressed into invasive cancer.[11]

The accidental harm from screening mammography has been underestimated. Women who have mammograms end up with increased surgeries, chemotherapy, radiotherapy and other potentially procedures resulting from the over-detection of harmless lumps. Many women will experience important psychological distress for many months because of false positive findings.[9] Half of suspicious findings will not become dangerous or will disappear over time.[9] Consequently, the value of routine mammography in women at low or average risk is controversial.[9] With unnecessary treatment of ten women for every one woman whose life was prolonged, the authors concluded that routine mammography may do more harm than good.[9] If 1,000 women in their 50s are screened every year for ten years, the following outcomes are considered typical in the developed world:[12]

The outcomes are worse for women in their 20s, 30s, and 40s, as they are far less likely to have a life-threatening breast cancer, and more likely to have dense breasts that make interpreting the mammogram more difficult. Among women in their 60s, who have a somewhat higher rate of breast cancer, the proportion of positive outcomes to harms are better:[14]

Mammography is not generally considered as an effective screening technique for women at average or low risk of developing cancer who are less than 50 years old. For normal-risk women 40 to 49 years of age, the risks of mammography outweigh the benefits,[15] and the US Preventive Services Task Force says that the evidence in favor of routine screening of women under the age of 50 is "weak".[16] Part of the difficulty in interpreting mammograms in younger women stems from breast density. Radiographically, a dense breast has a preponderance of glandular tissue, and younger age or estrogen hormone replacement therapy contribute to mammographic breast density. After menopause, the breast glandular tissue gradually is replaced by fatty tissue, making mammographic interpretation much more accurate.

Recommendations

Recommendations to attend to mammography screening vary across countries and organizations, with the most common difference being the age at which screening should begin, and how frequently or if it should be performed, among women at typical risk for developing breast cancer. For example, in England, all women were invited for screening once every three years beginning at age 50,[17] though this is transitioning to a start at age 47 by 2016.[18] Some other organizations recommend mammograms begin as early as age 40 in normal-risk women, and take place more frequently, up to once each year. Women at higher risk may benefit from earlier or more frequent screening. Women with one or more first-degree relatives (mother, sister, daughter) with premenopausal breast cancer often begin screening at an earlier age, perhaps at an age 10 years younger than the age when the relative was diagnosed with breast cancer.

As of 2009 the United States Preventive Services Task Force recommends that women over the age of 50 receive mammography once every two years.[16]

The Cochrane Collaboration (2011) states that the best quality evidence neither demonstrates a reduction in either cancer specific, nor a reduction in all cause mortality from screening mammography.[19] When less rigorous trials are added to the analysis there is a reduction in breast cancer specific mortality of 0.05% (a relative decrease of 15%).[19] Screening results in a 30% increase in rates of over-diagnosis and over-treatment, resulting in the view that it is not clear whether mammography screening does more good or harm.[19] On their Web site, Cochrane currently concludes that, due to recent improvements in breast cancer treatment, and the risks of false positives from breast cancer screening leading to unnecessary treatment, "it therefore no longer seems reasonable to attend for breast cancer screening" at any age.[11][20]

Breast density

Two mammograms of normal dense breasts.

Breasts are made up of breast tissue, connective tissue, and adipose (fat) tissue. The amount of each of the three types of tissue varies from woman to woman. Breast density is a measurement of relative amounts of these three tissues in a woman's breasts, as determined by their appearance on an X-ray image. Breast and connective tissues are radiographically denser (they produce a brighter white on an X-ray) than adipose tissue on a mammogram, so a woman with more breast tissue and/or more connective tissue is said to have greater breast density. Breast density is assessed by mammography and expressed as a percentage of the mammogram occupied by radiologically dense tissue (percent mammographic density or PMD).[21] About half of middle-aged women have dense breasts, and breasts generally become less dense as they age. On the one hand, higher breast density is associated with higher breast cancer risk in both premenopausal and postmenopausal women. On the other hand, women with extremely low densities have been recently shown to hold a significantly worse prognosis irrespective of patients' age, BMI and menopausal status.[22]

Breast cancers are difficult to detect through mammograms in women with high breast density because most cancers and dense breast tissues have a similar appearance on a mammogram. As a result, higher breast density is associated with a higher rate of false negatives (missed cancers).[23]

Health programs

In 2005, about 68% of all U.S. women age 40–64 had a mammogram in the past two years (75% of women with private health insurance, 56% of women with Medicaid insurance, 38% of currently uninsured women, and 33% of women uninsured for more than 12 months).[24] All U.S. states except Utah require private health insurance plans and Medicaid to pay for breast cancer screening.[25] As of 1998, Medicare (available to those aged 65 or older or who have been on Social Security Disability Insurance for over 2 years) pays for annual screening mammography in women aged 40 or older.

Three out of twelve (3/12) breast cancer screening programs in Canada offer clinical breast examinations.[26] All twelve offer screening mammography every two years for women aged 50–69, while nine out of twelve (9/12) offer screening mammography for women aged 40–49.[26] In 2003, about 61% of women aged 50–69 in Canada reported having had a mammogram within the past two years.[27]

The UK's NHS Breast Screening Programme, the first of its kind in the world, began in 1988 and achieved national coverage in the mid-1990s. It provides free breast cancer screening mammography every three years for all women in the UK aged between 50 and 70; the age range is currently being extended to 47 to 73, to be completed by 2016.[28] As 2006, about 76% of women aged 53–64 resident in England had been screened at least once in the previous three years.[29]

The Australian national breast screening program, BreastScreen Australia, was commenced in the early 1990s and invites women aged 50–69 to screening every 2 years. No routine clinical examination is performed, and the cost of screening is free to the point of diagnosis.

The Singapore national breast screening program, BreastScreen Singapore, is the only publicly funded national breast screening program in Asia, and enrolls women aged 50–64 for screening every two years. Like the Australian system, no clinical examination is performed routinely. Unlike most national screening systems, however, clients have to pay half of the cost of the screening mammogram; this is in line with the Singapore health system's core principle of co-payment for all health services.

Criticisms

Most women significantly overestimate both their own risk of dying from breast cancer and the effect screening mammography could have on it.[30] Some researchers worry that if women correctly understood that screening programs offer a small, but statistically significant benefit, more women would refuse to participate.[30]

The contribution of mammography to the early diagnosis of cancer is controversial, and for those found with benign lesions, mammography can create a high psychological and financial cost. Most women participating in mammography screening programs accept the risk of false positive recall, and the majority do not find it very distressing. Many patients find the recall very frightening, and are intensely relieved to discover that it was a false positive, as about 90% of women do.[31]

A major effect of routine breast screening is to greatly increase the rate of early breast cancer detection, in particular for non-invasive ductal carcinoma in situ (DCIS), sometimes called "pre-breast cancer", which almost never forms a lump and which generally cannot be detected except through mammography. While this ability to detect such very early breast malignancies is at the heart of claims that screening mammography can improve survival from breast cancer, it is also controversial. This is because a very large proportion of such cases will not progress to kill the patient, and thus mammography cannot be genuinely claimed to have saved any lives in such cases; in fact, it would lead to increased sickness and unnecessary surgery for such patients.

Consequently, finding and treating many cases of DCIS represents overdiagnosis and overtreatment. Treatment is given to all women with DCIS because it is currently impossible to predict which patients with DCIS will have an indolent, non-fatal course, and which few will inevitably progress to invasive cancer and premature death if left untreated. Consequently, all patients with DCIS are treated in much the same way, with at least wide local excision, and sometimes mastectomy if the DCIS is very extensive. The cure rate for DCIS if treated appropriately is extremely high, partly because the majority of DCIS cases were harmless in the first place.

The phenomenon of finding pre-invasive malignancy or nonmalignant benign disease is commonplace in all forms of cancer screening, including pap smears for cervical cancer, fecal occult blood testing for colon cancer, and prostate-specific antigen testing for prostate cancer. All of these tests have the potential to detect asymptomatic cancers, and all of them have a high rate of false positives and lead to invasive procedures that are unlikely to benefit the patient.

Molecular breast imaging

Molecular breast imaging is a nuclear medicine technique that is currently under study. It shows promising results for imaging people with dense breast tissue and may have accuracies comparable to MRI.[32] It may be better than mammography in some people with dense breast tissue, detecting two to three times more cancers in this population.[32] It however carries a greater risk of radiation damage making it inappropriate for general breast cancer screening.[33] It is possible to reduce the dose of radiation used.[34]

An earlier alternative technique suited to dense breast tissue, scintimammography is now not recommended by the American Cancer Society, which states, "This test cannot show whether an abnormal area is cancer as accurately as a mammogram, and it’s not used as a screening test. Some radiologists believe this test may be helpful in looking at suspicious areas found by mammogram. But the exact role of scintimammography is still unclear."[35]

Ultrasonography

Medical ultrasonography is a diagnostic aid to mammography. Adding ultrasonography testing for women with dense breast tissue increases the detection of breast cancer, but also increases false positives.[36][37]

Magnetic resonance imaging

Main article: Breast MRI

Magnetic resonance imaging (MRI) has been shown to detect cancers not visible on mammograms. The chief strength of breast MRI is its very high negative predictive value. A negative MRI can rule out the presence of cancer to a high degree of certainty, making it an excellent tool for screening in patients at high genetic risk or radiographically dense breasts, and for pre-treatment staging where the extent of disease is difficult to determine on mammography and ultrasound. MRI can diagnose benign proliferative change, fibroadenomas, and other common benign findings at a glance, often eliminating the need for costly and unnecessary biopsies or surgical procedures. The spatial and temporal resolution of breast MRI has increased markedly in recent years, making it possible to detect or rule out the presence of small in situ cancers, including ductal carcinoma in situ.

However, breast MRI has long been regarded to have disadvantages. For example, although it is 27–36% more sensitive, it has been claimed to be less specific than mammography.[38] As a result, MRI studies may have more false positives (up to 30%), which may have undesirable financial and psychological costs. It is also a relatively expensive procedure, and one which requires the intravenous injection of gadolinium, which has been implicated in a rare reaction called nephrogenic systemic fibrosis. Although NSF is extremely uncommon, patients with a history of renal disease may not be able to undergo breast MRI. Further, an MRI may not be used for screening patients with a pacemaker or breast reconstruction patients with a tissue expander due to the presence of metal.

Proposed indications for using MRI for screening include:[39]

In addition, breast MRI may be helpful for screening in women who have had breast augmentation procedures involving intramammary injections of various foreign substances that may mask the appearances of breast cancer on mammography and/or ultrasound. These substances include silicone oil and polyacrylamide gel.

BRCA testing

Genetic testing does not detect cancers, but may reveal a propensity to develop cancer. Women who are known to have a higher risk of developing breast cancer usually undertake more aggressive screening programs.

A clinical practice guideline by the US Preventive Services Task Force recommends against routine referral for genetic counseling or routine testing for BRCA mutations, on fair evidence that the harms outweigh the benefits.[40] It also encourages a referral for counseling and testing in women who have a family history that indicates they have an increased risk of a BRCA mutation, on fair evidence of benefit.[40] About 2% of American women have family histories that indicate an increased risk of having a medically significant BRCA mutation.[40]

Other

The nipple aspirate test is not indicated for breast cancer screening.[41]

Optical imaging, also known as diaphanography (DPG), multi-scan transillumination, and light scanning, is the use of transillumination to distinguish tissue variations. It is in the early stage of study.[42]

References

  1. 1 2 3 4 Kösters JP, Gøtzsche PC (2003). Kösters, Jan Peter, ed. "Regular self-examination or clinical examination for early detection of breast cancer". Cochrane Database Syst Rev (2): CD003373. doi:10.1002/14651858.CD003373. PMID 12804462.
  2. 1 2 Siu, Albert L. (12 January 2016). "Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement". Annals of Internal Medicine. doi:10.7326/M15-2886.
  3. ↑ Schonberg M. Breast cancer screening: at what age to stop? Consultant. 2010;50(May):196-205.
  4. ↑ Saslow D, Hannan J, Osuch J, et al. (2004). "Clinical breast examination: practical recommendations for optimizing performance and reporting". CA Cancer J Clin. 54 (6): 327–44. doi:10.3322/canjclin.54.6.327. PMID 15537576.
  5. 1 2 Clinic, Mayo (2012-11-16). The Mayo Clinic Breast Cancer Book. RosettaBooks. p. 124. ISBN 9780795334306.
  6. ↑ Reynolds, Handel (2012-08-07). The Big Squeeze: a social and political history of the controversial mammogram. Cornell University Press. p. 77. ISBN 0801465567.
  7. ↑ Croswell JM, Kramer BS, Kreimer AR, et al. (2009). "Cumulative incidence of false-positive results in repeated, multimodal cancer screening". Annals of Family Medicine. 7 (3): 212–22. doi:10.1370/afm.942. PMC 2682972Freely accessible. PMID 19433838.
  8. ↑ Smith-Bindman R, Ballard-Barbash R, Miglioretti DL, Patnick J, Kerlikowske K (2005). "Comparing the performance of mammography screening in the USA and the UK". Journal of Medical Screening. 12 (1): 50–4. doi:10.1258/0969141053279130. PMID 15814020.
  9. 1 2 3 4 5 6 Gøtzsche PC, Nielsen M (2011). "Screening for breast cancer with mammography". Cochrane Database Syst Rev (1): CD001877. doi:10.1002/14651858.CD001877.pub4. PMID 21249649.
  10. ↑ Harris R, Yeatts J, Kinsinger L (September 2011). "Breast cancer screening for women ages 50 to 69 years a systematic review of observational evidence". Prev Med. 53 (3): 108–14. doi:10.1016/j.ypmed.2011.07.004. PMID 21820465.
  11. 1 2 3 "Mammography-leaflet; Screening for breast cancer with mammography" (PDF). Retrieved 2012-06-24.
  12. ↑ Welch, H. Gilbert; Woloshin, Steve; Schwartz, Lisa A. (2011). Overdiagnosed: Making People Sick in the Pursuit of Health. Beacon Press. p. 149. ISBN 0-8070-2200-4.
  13. ↑ "Information on Mammography for Women Aged 40 and Older". 2010-01-05. Retrieved 28 April 2015.
  14. 1 2 Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L (November 2009). "Screening for breast cancer: an update for the U.S. Preventive Services Task Force". Annals of Internal Medicine. 151 (10): 727–37, W237–42. doi:10.1059/0003-4819-151-10-200911170-00009. PMC 2972726Freely accessible. PMID 19920273.
  15. ↑ Armstrong K, Moye E, Williams S, Berlin JA, Reynolds EE (2007). "Screening mammography in women 40 to 49 years of age: a systematic review for the American College of Physicians". Annals of Internal Medicine. 146 (7): 516–26. doi:10.7326/0003-4819-146-7-200704030-00008. PMID 17404354.
  16. 1 2 US Preventive Services Task Force (November 2009). "Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement". Annals of Internal Medicine. 151 (10): 716–26, W–236. doi:10.1059/0003-4819-151-10-200911170-00008. PMID 19920272.
  17. ↑ "Why are women under 50 not routinely invited for breast screening?", Public Health England, accessed 19 May 2014
  18. ↑ "Age Extension Full Randomised Control Trial", Public Health England, accessed 19 May 2014
  19. 1 2 3 Gøtzsche PC, Nielsen M (2011). "Screening for breast cancer with mammography". Cochrane Database Syst Rev (1): CD001877. doi:10.1002/14651858.CD001877.pub4. PMID 21249649.
  20. ↑ http://www.cochrane.dk/screening/index-en.htm
  21. ↑ Mammographic density and breast cancer risk: current understanding and future prospects
  22. ↑ Amro Masarwah; Päivi Auvinen; Mazen Sudah; Suvi Rautiainen; Anna Sutela; Outi Pelkonen; Sanna Oikari; Veli-Matti Kosma; Ritva Vanninen; et al. (2015). "Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer". European Radiology. 25: 1875–1882. doi:10.1007/s00330-015-3626-2. PMID 25735512.
  23. ↑ "The Impact of Breast Density on Breast Cancer Risk and Breast Screening". Current Breast Cancer Reports. 4: 161–168. June 2012. doi:10.1007/s12609-012-0070-z.
  24. ↑ Ward E, Halpern M, Schrag N, Cokkinides V, DeSantis C, Bandi P, Siegel R, Stewart A, Jemal A (January–February 2008). "Association of insurance with cancer care utilization and outcomes". CA Cancer J Clin. 58 (1): 9–31. doi:10.3322/CA.2007.0011. PMID 18096863.
  25. ↑ Kaiser Family Foundation (December 31, 2006). "State Mandated Benefits: Cancer Screening for Women, 2006".
  26. 1 2 "Organized Breast Cancer Screening Programs in Canada REPORT ON PROGRAM PERFORMANCE IN 2007 AND 2008" (PDF). cancerview.ca. Canadian Partnership Against Cancer. February 2013. Retrieved April 12, 2016.
  27. ↑ Canadian Cancer Society (April 2006). "Canadian Cancer Statistics, 2006" (PDF).
  28. ↑ NHS Cancer Screening Programmes (2015). "NHS Breast Screening Programme".
  29. ↑ The Information Centre (NHS) (March 23, 2007). "Breast Screening Programme 2005/06".
  30. 1 2 "Women 'misjudge screening benefits'". BBC News. 15 October 2001. Retrieved 2007-04-04.
  31. ↑ Welch, 2011. pp. 177–178.
  32. 1 2 O'Connor, M; Rhodes, D; Hruska, C (August 2009). "Molecular breast imaging". Expert review of anticancer therapy. 9 (8): 1073–80. doi:10.1586/era.09.75. PMC 2748346Freely accessible. PMID 19671027.
  33. ↑ Moade l, RM (May 2011). "Breast cancer imaging devices". Seminars in nuclear medicine. 41 (3): 229–41. doi:10.1053/j.semnuclmed.2010.12.005. PMID 21440698.
  34. ↑ O'Connor, MK; Li, H; Rhodes, DJ; Hruska, CB; Clancy, CB; Vetter, RJ (December 2010). "Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast". Medical Physics. 37 (12): 6187–98. doi:10.1118/1.3512759. PMID 21302775.
  35. ↑ "Experimental and other breast imaging". American Cancer Society. Retrieved 10 December 2013.
  36. ↑ Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, et al. (2008). "Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.". JAMA. 299 (18): 2151–63. doi:10.1001/jama.299.18.2151. PMC 2718688Freely accessible. PMID 18477782. Review in: J Fam Pract. 2008 Aug;57(8):508
  37. ↑ Berg WA, Zhang Z, Lehrer D, Jong RA, Pisano ED, Barr RG, et al. (2012). "Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk.". JAMA. 307 (13): 1394–404. doi:10.1001/jama.2012.388. PMID 22474203.
  38. ↑ Hrung J, Sonnad S, Schwartz J, Langlotz C (1999). "Accuracy of MR imaging in the work-up of suspicious breast lesions: a diagnostic meta-analysis". Acad Radiol. 6 (7): 387–97. doi:10.1016/S1076-6332(99)80189-5. PMID 10410164.
  39. ↑ Morrow M (2004). "Magnetic resonance imaging in breast cancer: one step forward, two steps back?". JAMA. 292 (22): 2779–80. doi:10.1001/jama.292.22.2779. PMID 15585740.
  40. 1 2 3 "Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Recommendation Statement". Agency for Healthcare Research and Quality. United States Preventive Services Task Force. September 2005. Retrieved 2011-03-07.
  41. ↑ "Breast Cancer Screening - Nipple Aspirate Test Is Not An Alternative To Mammography: FDA Safety Communication". Retrieved 28 July 2016.
  42. ↑ Godavarty, A; Rodriguez, S; Jung, YJ; Gonzalez, S (2015). "Optical imaging for breast cancer prescreening.". Breast cancer (Dove Medical Press). 7: 193–209. PMID 26229503.
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