Dihydrobenzophenanthridine oxidase

Dihydrobenzophenanthridine oxidase (DHBP oxidase) is an enzyme. In the IUBMB Enzyme Nomenclature, Dihydrobenzophenanthridine oxidase is EC 1.5.3.12. Dihydrobenzophenanthridine oxidase/EC 1.5.3.12 produces oxidized forms of benzophenanthridine alkaloids:

In Sanguinaria Canadensis EC 1.5.3.12 produces sanguinarine from dihydrosanguinarine, and chelirubine from dihydrochelirubine.
In California poppy, EC 1.5.3.12 produces macarpine from dihydromacarpine.

External links

EC 1.5.3.12 International Union of Biochemistry and Molecular Biology, Recommendations on Biochemical & Organic Nomenclature, Symbols & Terminology etc., web interface.
Chelirubine, Macarpine, and Sanguinarine Biosynthesis ibid.
Ignatov A, Clark WG, Cline SD, Psenak M, Krueger J, Coscia CJ (1996). "Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures". Phytochemistry. 43 (6): 1141–4. doi:10.1016/S0031-9422(96)00540-7. PMID 8987906.
Park SU, Yu M, Facchini PJ (2002). "Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy". Plant Physiol. 128 (2): 696–706. doi:10.1104/pp.010741. PMC 148930. PMID 11842172.
Rho D, Chauret N, Laberge N, Archambault J (1992). "Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids". Appl. Microbiol. Biotechnol. 36 (5): 611–7. doi:10.1007/BF00183237. PMID 1368065.
KEGG (Kyoto Encyclopedia of Genes and Genomes) Alkaloid biosynthesis I - Reference pathway

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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