GNB1

GNB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases GNB1
External IDs MGI: 95781 HomoloGene: 55532 GeneCards: GNB1
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

2782

14688

Ensembl

ENSG00000078369

ENSMUSG00000029064

UniProt

P62873

P62874

RefSeq (mRNA)

NM_002074
NM_001282538
NM_001282539

NM_001160016
NM_001160017
NM_008142

RefSeq (protein)

NP_001269467.1
NP_001269468.1
NP_002065.1

NP_001153488.1
NP_001153489.1
NP_032168.1

Location (UCSC) Chr 1: 1.79 – 1.89 Mb Chr 4: 155.49 – 155.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[3]

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:429.0px; top:646px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:142.0px; top:421px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:62px; height:0px; overflow:hidden; position:relative; left:693.0px; top:561px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:545.0px; top:144px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:352.0px; top:192px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:234.0px; top:388px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:446.0px; top:45px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:50px; height:0px; overflow:hidden; position:relative; left:248.0px; top:593px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:815px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:249.29411764705878px; top:671.949579831933px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:380.0px; top:464px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:433.0px; top:532px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:776px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:795px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:369.0px; top:505px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:146px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:42px; height:0px; overflow:hidden; position:relative; left:518.0px; top:551px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:167px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:255.0px; top:125px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:401.0px; top:775px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:429.0px; top:626px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:207px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:186px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:255.0px; top:236px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:618.4705882352949px; top:730.210084033613px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:816px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:45px; height:0px; overflow:hidden; position:relative; left:190.0px; top:596px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:246.0px; top:820px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:53.25px; height:0px; overflow:hidden; position:relative; left:296.75px; top:556.25px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; left:619.0px; top:187px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:619.3025210084037px; top:666.521008403362px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:46px; height:0px; overflow:hidden; position:relative; left:697.7310924369746px; top:643.36974789916px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:614.5084033613451px; top:610.184873949579px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:142.0px; top:441px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:780px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:49px; height:0px; overflow:hidden; position:relative; left:455.0px; top:796px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:206px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:443.0px; top:413px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:39px; height:0px; overflow:hidden; position:relative; left:698.7058823529412px; top:698.865546218488px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:85.0px; top:388px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:760px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:614.6050420168065px; top:497.857142857143px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:43px; height:0px; overflow:hidden; position:relative; left:305.0px; top:125px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:56px; height:0px; overflow:hidden; position:relative; left:447.0px; top:166px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:54px; height:0px; overflow:hidden; position:relative; left:352.0px; top:172px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:43px; height:0px; overflow:hidden; position:relative; left:305.0px; top:236px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; left:494.0px; top:590px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:68px; height:0px; overflow:hidden; position:relative; left:816.4537815126054px; top:497.857142857143px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:40px; height:0px; overflow:hidden; position:relative; left:493.0px; top:253px; background:transparent; border-top:3px blue solid"></div>]]
[[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; left:254.5px; top:800px; background:transparent; border-top:3px blue solid"></div>]]
[[
]]
NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article

|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNB1 has been shown to interact with GNG4.[4][5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1".
  4. Ray K, Kunsch C, Bonner LM, Robishaw JD (September 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
  5. Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.