GNA12

GNA12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZCA
Identifiers
Aliases	GNA12, NNX3, RMP, gep, G protein subunit alpha 12
External IDs	MGI: 95767 HomoloGene: 22398 GeneCards: GNA12
Genetically Related Diseases
ulcerative colitis[1]
Gene ontology Molecular function • nucleotide binding • GTP binding • metal ion binding • protein binding • GTPase activity • guanyl nucleotide binding • G-protein coupled receptor binding • D5 dopamine receptor binding • signal transducer activity • G-protein beta/gamma-subunit complex binding Cellular component • membrane • focal adhesion • plasma membrane • heterotrimeric G-protein complex • brush border membrane Biological process • cell differentiation • intracellular signal transduction • regulation of TOR signaling • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • small GTPase mediated signal transduction • embryonic digit morphogenesis • blood coagulation • in utero embryonic development • platelet activation • regulation of cell shape • regulation of proteasomal ubiquitin-dependent protein catabolic process • response to drug • signal transduction • G-protein coupled receptor signaling pathway • regulation of fibroblast migration • Rho protein signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2768	14673
Ensembl	ENSG00000146535	ENSMUSG00000000149
UniProt	Q03113	P27600
RefSeq (mRNA)	NM_001282440 NM_001282441 NM_001293092 NM_007353	NM_010302
RefSeq (protein)	NP_001269370.1 NP_001280021.1 NP_031379.2	NP_034432.1
Location (UCSC)	Chr 7: 2.73 – 2.84 Mb	Chr 5: 140.76 – 140.83 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.^[4][5][6]

Interactions

GNA12 has been shown to interact with ARHGEF1,^[7] PPP5C,^[8] ARHGEF12,^[9][10] Heat shock protein 90kDa alpha (cytosolic), member A1^[11] and TEC.^[10]

See also

• G12/G13 alpha subunits

References

1. "Diseases that are genetically associated with GNA12 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. PMC 358958. PMID 8423800.
5. Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
6. "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
7. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
8. Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
9. Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2-3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
10. Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
11. Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.

External links

• GNA12 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)