Haplogroup H (mtDNA)

Haplogroup H
Possible time of origin 20,000-25,000 YBP
Possible place of origin Southwest Asia[1]
Ancestor HV[1]
Descendants H* lineages, H1, H2, H3, H4, H5'36, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, H16, H18, H19, H20, H22, H23, H24, H25, H26, H28, H29, H31, H32, H33, H34, H35, H37, H38, H39, 16129(H17+H27), 16129(H21+H30)
Defining mutations G2706A, T7028C[2]

Haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup. The clade is believed to have originated in Southwest Asia,[1] around 20,000-25,000 years ago.

Mitochondrial haplogroup H is today predominantly found in Europe, and is believed to have evolved before the Last Glacial Maximum (LGM). It first expanded in the northern Near East and Southern Caucasus between 33,000 and 26,000 years ago, and later migrations from Iberia suggest it reached Europe before the Last Glacial Maximum. The clade has also spread to Siberia and inner Asia. Today, about 40% of all maternal lineages in Europe belong to haplogroup H.

Origin

Haplogroup H is a descendant of haplogroup HV. The Cambridge Reference Sequence (CRS), which until recently was the human mitochondrial sequence to which all others were compared, belongs to haplogroup H2a2a1 (human mitochondrial sequences should now be compared with the ancestral Reconstructed Sapiens Reference Sequence (RSRS)).[3] Several independent studies conclude that haplogroup H probably evolved in West Asia c. 25,000 years ago. It was carried to Europe by migrations c. 20-25,000 years ago, and spread with population of the southwest of the continent.[4][5] Its arrival was roughly contemporary with the rise of the Gravettian culture. The spread of subclades H1, H3 and the sister haplogroup V reflect a second intra-European expansion from the Franco-Cantabrian region after the last glacial maximum, c. 13,000 years ago.[1][4]

In July 2008 ancient mtDNA from an individual called Paglicci 23, whose remains were dated to 28,000 years ago and excavated from Paglicci Cave (Apulia, Italy), were found to be identical to the Cambridge Reference Sequence in HVR1.[6] This once was believed to indicate haplogroup H, but researchers now recognize that CRS can also appear in U or HV. Haplogroup HV derives from the Haplogroup R0 which in turn derives from haplogroup R is a descendant of macro-haplogroup N like its sibling M, is a descendant of haplogroup L3.

Haplogroup H has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[7]

Haplogroup H has been observed among specimens at the mainland cemetery in Kulubnarti, Sudan, which date from the Early Christian period (AD 550-800).[8]

Distribution

Projected spatial frequency distributions for haplogroups H*, H1, H2a, H3, H4, H5a, H6a, H7, H8 and H11.

Haplogroup H is the most common mtDNA clade in Europe.[9] It is found in approximately 41% of native Europeans.[10][11] The lineage is also common in North Africa and the Middle East.[12]

The majority of the European populations have an overall haplogroup H frequency of 40%–50%. Frequencies decrease in the southeast of the continent. The clade reaches 20% in the Near East and Caucasus, 17% in Iran, and <10% in the Persian Gulf, Northern India and Central Asia.[1][13]

Undifferentiated haplogroup H has been found among Palestinians (14%),[14] Syrians (13.6%),[14] Druze (10.6%),[14] Iraqis (9.5%),[14] Somalis (6.7%),[14] Egyptians (5.7% in El-Hayez;[15] 14.7% in Gurna[16]), Saudis (5.3%-10%),[14] Socotri (3.1%),[17] Nubians (1.3%),[14] and Yemenis (0%-13.9%).[14]

Subclades

Among all these clades, the subhaplogroups H1 and H3 have been subject to a more detailed study and would be associated to the Magdalenian expansion from SW Europe c. 13,000 years ago:[4]

H1

Projected spatial frequency distribution of haplogroup H1.

H1 encompasses an important fraction of Western European mtDNA lineages, reaching its local peak among contemporary Basques (27.8%). It also occurs at high frequencies elsewhere in the Iberian Peninsula, as well as in the Maghreb. The haplogroup frequency is above 10% in many other parts of Europe (France, Sardinia, British Isles, Alps, large portions of Eastern Europe), and above 5% in nearly all the continent.[1] Its subclade H1b is most common in eastern Europe and NW Siberia.[18]

So far, the highest frequency of H1 has been found among the Tuareg inhabiting the Fezzan region in Libya (61%).[19][20] The basal H1* haplogroup is found among the Tuareg inhabiting the Gossi area in Mali (4.76%).[21]

Frequencies of haplogroup H1 in the world (Ottoni et al. 2010)
Region or Population H1% No. of subjects
Africa
Libyan Tuareg61129
Tuareg (West Sahel)23.390
Berbers (Morocco)20.2217
Morocco12.2180
Berbers (Tunisia)13.4276
Tunisia 10.6269
Mozabite9.880
Siwas (Egypt) 1.1184
Western Sahara14.8128
Mauritania6.9102
Senegal 0100
Fulani (Chad-Cameroon)0186
Cameroon0142
Chad 077
Buduma (Niger)030
Nigeria069
Ethiopia082
Amhara (Ethiopia)090
Oromo (Ethiopia)0117
Sierra Leone0155
Guineans (Guiné Bissau)0372
Mali083
Kikuyu (Kenya)024
Benin0192
Asia
Central Asia0.7445
Pakistan0100
Yakuts 1.758
Caucasus
Caucasus (north) 8.868
Caucasus (south)2.3132
Northwestern Caucasus4.7234
Armenians2.3175
Daghestan2.5269
Georgians1193
Karachay-Balkars4.4203
Ossetians2.4296
Europe
Andalusia 24.3103
Basques (Spain) 27.8108
Catalonia13.9101
Galicia17.7266
Pasiegos (Cantabria) 23.551
Portugal25.5499
Spain (miscellaneous) 18.9132
Italy (north) 11.5322
Italy (center) 6.3208
Italy (south)8.7206
Sardinia 17.9106
Sicily 1090
Finland 1878
Volga-Ural Finnic speakers13.6125
Basques (France) 17.540
Béarnaise 14.827
France12.3106
Estonia16.7114
Saami057
Lithuania1.7180
Hungary 11.3303
Czech Republic 10.8102
Ukraine9.9191
Poland9.386
Russia13.5312
Austria10.62487
Germany6100
Romania9.4360
Netherlands 8.834
Greece (Aegean islands) 1.6247
Greece (mainland) 6.379
Macedonia 7.1252
Albania2.9105
Turks3.3360
Balkans5.4111
Croatia 8.384
Slovaks7.6119
Slovak (East)16.8137
Slovak (West)14.270
Middle East
Arabian Peninsula094
Arabian Peninsula (incl. Yemen, Oman) 0.8493
Druze 3.458
Dubai (United Arab Emirates)0.4249
Iraq1.9206
Jordanians1.7173
Lebanese4.2167
Syrians0159

H3

H3 is found throughout the whole of Europe and in the Maghreb but does not exist in the Far East,[22] and is believed to have originated among Mesolithic hunter-gatherers in south-western Europe between 9 000 and 11 000 years ago. H3 represents the second largest fraction of the H genome after H1 and has a somewhat similar distribution, with peaks in Portugal, Spain, Scandinavia and Finland. It is common in Portugal (12%), Sardinia (11%), Galicia (10%), the Basque country (10%), Ireland (6%), Norway (6%), Hungary (6%) and southwestern France (5%).[1][23][24] Studies have suggested haplogroup H3 is highly protective against AIDS progression.[25]

Example of H3 sub-groups are:[24]

The basal H3* haplogroup is found among the Tuareg inhabiting the Gossi area in Mali (4.76%).[21]

H5

Main article: Haplogroup H5 (mtDNA)

H5 may have evolved in West Asia, where it is most frequent and diverse in the Western Caucasus. However, its H5a subclade has a stronger representation in Europe, though at low levels.[27]

H2, H6 and H8

The H2, H6 and H8 haplogroups are somewhat common in Eastern Europe and the Caucasus.[4] They may be the most common H subclades among Central Asians and have also been found in West Asia.[18] H2a5 has been found in the Basque Country, Spain,[28] and in Norway, Ireland and Slovakia.[29] H6a1a1a is common among Ashkenazi Jews.[30]

H4, H7 and H13

These H4, H7 and H13 subhaplogroups are present in both Europe and West Asia; the H13 subclade is also found in the Caucasus. They are quite rare.[4] H4 is often found in Iberia [28] and along with H13 and H2 account for 42% of H lineages in Egypt.[31]

H11

H11 is commonly found in Central Europe.[28]

H18

H18 occurs on the Arabian Peninsula. [32]

H20 and H21

These haplogroups are both found in the Caucasus region.[27] H20 also appears at low levels in the Iberian Peninsula (less than 1%), Arabian Peninsula (1%) and Near East (2%).[32]

H22 through H95a

These subclades are found mostly in Europe, South-West Asia and Central Asia.

Tree

Phylogenetic tree of haplogroup H

This phylogenetic tree of haplogroup H subclades is based on Build 16(February 2014) of the Phylotree, an internationally accepted standard.[33] The full tree can be viewed at Phylotree.

Genetic traits

Haplogroup H was found as a possible increased risk factor for ischemic cardiomyopathy development.[34]

Popular culture

In his popular book The Seven Daughters of Eve, Bryan Sykes named the originator of this mtDNA haplogroup Helena. Stephen Oppenheimer uses the very similar name Helina in his book The Origins of the British.

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M   N  
CZ D E G Q   O A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References

  1. 1 2 3 4 5 6 7 Achilli A, Rengo C, Magri C, et al. (November 2004). "The Molecular Dissection of mtDNA Haplogroup H Confirms That the Franco-Cantabrian Glacial Refuge Was a Major Source for the European Gene Pool". American Journal of Human Genetics. 75 (5): 910–8. doi:10.1086/425590. PMC 1182122Freely accessible. PMID 15382008.
  2. ↑ van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457.
  3. ↑ Behar DM, van Oven M, Rosset S, Metspalu M, Loogvali E-L Silva NM, Kivisild T, Torroni A, Villems R (2012). "A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root". Am. J. Hum. Genet. 90 (4): 675–84. doi:10.1016/j.ajhg.2012.03.002. PMC 3322232Freely accessible. PMID 22482806.
  4. 1 2 3 4 5 Pereira L, Richards M, Goios A, et al. (January 2005). "High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium". Genome Research. 15 (1): 19–24. doi:10.1101/gr.3182305. PMC 540273Freely accessible. PMID 15632086.
  5. ↑ Richards M, Macaulay V, Hickey E, et al. (November 2000). "Tracing European Founder Lineages in the Near Eastern mtDNA Pool". American Journal of Human Genetics. 67 (5): 1251–76. doi:10.1016/S0002-9297(07)62954-1. PMC 1288566Freely accessible. PMID 11032788.
  6. ↑ Caramelli D, Milani L, Vai S, et al. (2008). Harpending H, ed. "A 28,000 Years Old Cro-Magnon mtDNA Sequence Differs from All Potentially Contaminating Modern Sequences". PLOS ONE. 3 (7): e2700. doi:10.1371/journal.pone.0002700. PMC 2444030Freely accessible. PMID 18628960.
  7. ↑ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González. "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14: 109. doi:10.1186/1471-2148-14-109.
  8. ↑ Sirak, Kendra; Frenandes, Daniel; Novak, Mario; Van Gerven, Dennis; Pinhasi, Ron (2016). Abstract Book of the IUAES Inter-Congress 2016 - A community divided? Revealing the community genome(s) of Medieval Kulubnarti using next- generation sequencing. IUAES.
  9. ↑ Ghezzi D, Marelli C, Achilli A, et al. (June 2005). "Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians". European Journal of Human Genetics. 13 (6): 748–52. doi:10.1038/sj.ejhg.5201425. PMID 15827561.
  10. ↑ Bryan Sykes (2001). The Seven Daughters of Eve. London; New York: Bantam Press. ISBN 0393020185.
  11. ↑ "Maternal Ancestry". Oxford Ancestors. Retrieved 7 February 2013.
  12. ↑ "Haplogroup H". Atlas of the Human Journey - The Genographic Project. National Geographic.
  13. ↑ Metspalu M, Kivisild T, Metspalu E, et al. (August 2004). "Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans". BMC Genetics. 5: 26. doi:10.1186/1471-2156-5-26. PMC 516768Freely accessible. PMID 15339343.
  14. 1 2 3 4 5 6 7 8 Non, Amy. "ANALYSES OF GENETIC DATA WITHIN AN INTERDISCIPLINARY FRAMEWORK TO INVESTIGATE RECENT HUMAN EVOLUTIONARY HISTORY AND COMPLEX DISEASE" (PDF). University of Florida. Retrieved 3 May 2016.
  15. ↑ Martina Kujanova; Luisa Pereira; Veronica Fernandes; Joana B. Pereira; Viktor Cerny (2009). "Near Eastern Neolithic Genetic Input in a Small Oasis of the Egyptian Western Desert". American Journal of Physical Anthropology. 140 (2): 336–346. doi:10.1002/ajpa.21078. PMID 19425100.
  16. ↑ A. Stevanovitch; A. Gilles; E. Bouzaid; R. Kefi; F. Paris; R. P. Gayraud; J. L. Spadoni; F. El-Chenawi; E. Béraud-Colomb (January 2004). "Mitochondrial DNA Sequence Diversity in a Sedentary Population from Egypt". Annals of Human Genetics. 68 (1): 23–39. doi:10.1046/j.1529-8817.2003.00057.x. PMID 14748828. Retrieved 3 May 2016.
  17. ↑ Černý, Viktor; et al. (2009). "Out of Arabia—the settlement of island Soqotra as revealed by mitochondrial and Y chromosome genetic diversity" (PDF). American journal of Physical Anthropology. 138 (4): 439–447. doi:10.1002/ajpa.20960. Retrieved 12 June 2016.
  18. 1 2 Loogväli EL, Roostalu U, Malyarchuk BA, et al. (November 2004). "Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia". Molecular Biology and Evolution. 21 (11): 2012–21. doi:10.1093/molbev/msh209. PMID 15254257.
  19. ↑ Ottoni et al. 2010, "Mitochondrial Haplogroup H1 in North Africa: An Early Holocene Arrival from Iberia", Plosone
  20. ↑ Ottoni et al., "Table of frequencies of haplogroup H1 in the world", Plosone
  21. 1 2 Luísa Pereira; Viktor Černý; María Cerezo; Nuno M Silva; Martin Hájek; Alžběta Vašíková; Martina Kujanová; Radim Brdička; Antonio Salas (17 March 2010). "Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel". European Journal of Human Genetics. 18: 915–923. doi:10.1038/ejhg.2010.21. Retrieved 23 May 2016.
  22. ↑ Achilli A, Rengo C, Magri C, et al. (November 2004). "The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool". Am. J. Hum. Genet. 75: 910–8. doi:10.1086/425590. PMC 1182122Freely accessible. PMID 15382008.
  23. ↑ http://www.eupedia.com/europe/origins_haplogroups_europe.shtml#H Euopedia
  24. 1 2 http://www.eupedia.com/europe/Haplogroup_H_mtDNA.shtml Access date 2015/10/02
  25. ↑ Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, et al. (November 2008). "Mitochondrial DNA Haplogroups influence AIDS Progression". AIDS. 22 (18): 2429–39. doi:10.1097/QAD.0b013e32831940bb. PMC 2699618Freely accessible. PMID 19005266.
  26. ↑ https://www.familytreedna.com/public/mtdna_h3/default.aspx?section=mtresults Access date 2015/10/02
  27. 1 2 U. Roostalu et al, Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspective, Molecular Biology and Evolution, vol. 24, no. 2 (2007), pp. 436-448.
  28. 1 2 3 Alvarez-Iglesias V, Mosquera-Miguel A, Cerezo M, et al. (2009). MacAulay V, ed. "New Population and Phylogenetic Features of the Internal Variation within Mitochondrial DNA Macro-Haplogroup R0". PLOS ONE. 4 (4): e5112. doi:10.1371/journal.pone.0005112. PMC 2660437Freely accessible. PMID 19340307.
  29. ↑ van Oven M, Kayser M (2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Hum Mutat. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457.
  30. ↑ http://www.academia.edu/4718697/A_substantial_prehistoric_European_ancestry_amongst_Ashkenazi_maternal_lineages
  31. ↑ Bekada, Fregel, Cabrera, Larruga, Pestano, Benhamamouch and. González . (2013). "Introducing the Algerian Mitochondrial DNA and Y-Chromosome Profiles into the North African Landscape". PLOS ONE.
  32. 1 2 Ennafaa H, Cabrera VM, Abu-Amero KK, et al. (2009). "Mitochondrial DNA haplogroup H structure in North Africa". BMC Genetics. 10: 8. doi:10.1186/1471-2156-10-8. PMC 2657161Freely accessible. PMID 19243582.
  33. ↑ "PhyloTree.org mtDNA subtree R0".
  34. ↑ Fernández-Caggiano, Maria; Javier Barallobre-Barreiro; Ignacio Rego-Pérez; María G. Crespo-Leiro; María Jesus Paniagua; Zulaika Grillé; Francisco J. Blanco; Nieves Doménech (2012). "Mitochondrial Haplogroups H and J: Risk and Protective Factors for Ischemic Cardiomyopathy". PLOS ONE. 7 (8): e44128. doi:10.1371/journal.pone.0044128. PMC 3429437Freely accessible. PMID 22937160. Retrieved 16 April 2014.

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