Interleukin-10 receptor
| interleukin 10 receptor, alpha | |
|---|---|
| Identifiers | |
| Symbol | IL10RA |
| Alt. symbols | IL10R |
| Entrez | 3587 |
| HUGO | 5964 |
| OMIM | 146933 |
| RefSeq | NM_001558 |
| UniProt | Q13651 |
| Other data | |
| Locus | Chr. 11 q23 |
| interleukin 10 receptor, beta | |
|---|---|
| Identifiers | |
| Symbol | IL10RB |
| Alt. symbols | CRFB4, D21S58, D21S66 |
| Entrez | 3588 |
| HUGO | 5965 |
| OMIM | 123889 |
| RefSeq | NM_000628 |
| UniProt | Q08334 |
| Other data | |
| Locus | Chr. 21 q22.1-22.2 |
Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α[1] and 2β[2] subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.
References
- ↑ Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391.
- ↑ Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220
. PMID 9312047.
External links
- Receptors, Interleukin-10 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.