IL18R1

IL18R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WO3, 3WO4, 4R6U
Identifiers
Aliases	IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1
External IDs	MGI: 105383 HomoloGene: 2861 GeneCards: IL18R1
Genetically Related Diseases
asthma[1]
Gene ontology Molecular function • interleukin-18 receptor activity • protein binding • receptor activity • interleukin-1 receptor activity Cellular component • integral component of membrane • plasma membrane • membrane Biological process • interleukin-18-mediated signaling pathway • natural killer cell activation • positive regulation of interferon-gamma production • positive regulation of NF-kappaB import into nucleus • T-helper 1 cell differentiation • immune response • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8809	16182
Ensembl	ENSG00000115604	ENSMUSG00000026070
UniProt	Q13478	Q61098
RefSeq (mRNA)	NM_001282399 NM_003855	NM_001161842 NM_001161843 NM_008365
RefSeq (protein)	NP_001269328.1 NP_003846.1	NP_032391.1
Location (UCSC)	Chr 2: 102.31 – 102.4 Mb	Chr 1: 40.47 – 40.5 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.^[4] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.^[4]

See also

• Interleukin-18 receptor

References

1. "Diseases that are genetically associated with IL18R1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: IL18R1 interleukin 18 receptor 1".

Further reading

• Sergi B, Penttila I (2005). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
• Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
• Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
• Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
• Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
• Hoshino K, Tsutsui H, Kawai T, et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor". J. Immunol. 162 (9): 5041–4. PMID 10227969.
• Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells". J. Immunol. 165 (4): 1933–8. doi:10.4049/jimmunol.165.4.1933. PMID 10925275.
• Kumar S, Hanning CR, Brigham-Burke MR, et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production". Cytokine. 18 (2): 61–71. doi:10.1006/cyto.2002.0873. PMID 12096920.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gutzmer R, Langer K, Mommert S, et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18". J. Immunol. 171 (12): 6363–71. doi:10.4049/jimmunol.171.12.6363. PMID 14662834.
• Azam T, Novick D, Bufler P, et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex". J. Immunol. 171 (12): 6574–80. doi:10.4049/jimmunol.171.12.6574. PMID 14662859.
• Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
• Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha". Eur. J. Immunogenet. 31 (1): 27–9. doi:10.1111/j.1365-2370.2004.00441.x. PMID 15009178.
• Reddy SA, Lin YF, Huang HJ, et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087.
• Yoon- DY, Cho YS, Park JW, et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor". Clin. Chem. Lab. Med. 42 (5): 499–506. doi:10.1515/CCLM.2004.085. PMID 15202785.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Sahar S, Dwarakanath RS, Reddy MA, et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756.

External links

• IL18R1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.