Interleukin 30

IL27
Identifiers
Aliases	IL27, IL-27, IL-27A, IL27A, IL27p28, IL30, p28, Interleukin 30, IL-30, interleukin 27
External IDs	MGI: 2384409 HomoloGene: 17087 GeneCards: IL27
Gene ontology Molecular function • cytokine activity • interleukin-27 receptor binding • receptor binding Cellular component • extracellular space • extracellular region Biological process • innate immune response • inflammatory response • regulation of T-helper 1 cell differentiation • regulation of defense response to virus • response to bacterium • immune system process • positive regulation of interferon-gamma biosynthetic process • regulation of T cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246778	246779
Ensembl	ENSG00000197272	ENSMUSG00000044701
UniProt	Q8NEV9	Q8K3I6
RefSeq (mRNA)	NM_145659	NM_145636
RefSeq (protein)	NP_663634.2	NP_663611.1
Location (UCSC)	Chr 16: 28.5 – 28.51 Mb	Chr 7: 126.59 – 126.59 Mb
PubMed search	[1]	[2]
Wikidata

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Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.^[3] This gene for this molecule is now officially called IL-27 under HGNC guidelines.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
4. http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157