ITGB8

ITGB8
Identifiers
Aliases ITGB8
External IDs MGI: 1338035 HomoloGene: 18567 GeneCards: ITGB8
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

3696

320910

Ensembl

ENSG00000105855

ENSMUSG00000025321

UniProt

P26012

n/a

RefSeq (mRNA)

NM_002214

NM_177290

RefSeq (protein)

NP_002205.1

n/a

Location (UCSC) Chr 7: 20.33 – 20.42 Mb Chr 12: 119.16 – 119.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[3]

Function

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[3] Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.[4]

Clinical significance

High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: ITGB8 integrin, beta 8".
  4. Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH (January 2012). "αvβ8 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion". Mol Bio Cell. 24 (4): 474–82. doi:10.1091/mbc.E12-07-0521. PMID 23283986.
  5. Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011). "Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin". Cancer Res. 71 (20): 6371–81. doi:10.1158/0008-5472.CAN-11-0991. PMC 3193578Freely accessible. PMID 21859829.

Further reading

External links


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