ITGAV

ITGAV
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Identifiers
Aliases	ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
External IDs	MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV
Gene ontology Molecular function • transforming growth factor beta binding • metal ion binding • voltage-gated calcium channel activity • virus receptor activity • protein kinase C binding • protease binding • extracellular matrix protein binding • extracellular matrix binding • fibronectin binding • opsonin binding • insulin-like growth factor I binding • protein binding • fibroblast growth factor binding • neuregulin binding • coreceptor activity • C-X3-C chemokine binding Cellular component • lamellipodium membrane • integrin alphav-beta3 complex • extracellular exosome • alphav-beta3 integrin-IGF-1-IGF1R complex • integral component of membrane • integrin alphav-beta5 complex • membrane • focal adhesion • intracellular • integrin alphav-beta8 complex • ruffle membrane • integrin complex • microvillus membrane • filopodium membrane • external side of plasma membrane • phagocytic vesicle • plasma membrane • integral component of plasma membrane • cell surface Biological process • regulation of phagocytosis • angiogenesis • apoptotic cell clearance • endodermal cell differentiation • apolipoprotein A-I-mediated signaling pathway • negative chemotaxis • negative regulation of lipid storage • negative regulation of low-density lipoprotein particle receptor biosynthetic process • extracellular matrix organization • heterotypic cell-cell adhesion • positive regulation of cell migration • regulation of apoptotic cell clearance • substrate adhesion-dependent cell spreading • vascular endothelial growth factor receptor signaling pathway • cell-matrix adhesion • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • viral entry into host cell • blood vessel development • negative regulation of entry of bacterium into host cell • integrin-mediated signaling pathway • positive regulation of cell proliferation • calcium ion transmembrane transport • negative regulation of macrophage derived foam cell differentiation • negative regulation of extrinsic apoptotic signaling pathway • leukocyte migration • cell-substrate adhesion • entry of symbiont into host cell by promotion of host phagocytosis • negative regulation of lipoprotein metabolic process • negative regulation of lipid transport • cell migration • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cell adhesion • ERK1 and ERK2 cascade • cell growth • positive regulation of osteoblast proliferation • cell adhesion • cell adhesion mediated by integrin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3685	16410
Ensembl	ENSG00000138448	ENSMUSG00000027087
UniProt	P06756	P43406
RefSeq (mRNA)	NM_001144999 NM_001145000 NM_002210	NM_008402
RefSeq (protein)	NP_001138471.1 NP_001138472.1 NP_002201.1	NP_032428.2
Location (UCSC)	Chr 2: 186.59 – 186.68 Mb	Chr 2: 83.72 – 83.81 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.^[3]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.^[4]

Alpha V class integrins

In mammals the integrins that include alpha-V are :

Name	Synonyms	Distribution	Ligands
αVβ1		ocular melanoma; neurological tumors	vitronectin; fibrinogen
αVβ3	vitronectin receptor[5]	activated endothelial cells, melanoma, glioblastoma	vitronectin,[5] fibronectin, fibrinogen, osteopontin, Cyr61
αVβ5		widespread, esp. fibroblasts, epithelial cells	vitronectin and adenovirus
αVβ6		proliferating epithelia, esp. lung and mammary gland	fibronectin; TGFβ1+3
αVβ8		neural tissue; peripheral nerve	fibronectin; TGFβ1+3

As a drug target

The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.^[6]

See also

• Cluster of differentiation

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
4. "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)".
5. Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999). "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23". J. Cell Biol. 144 (4): 767–75. doi:10.1083/jcb.144.4.767. PMC 2132927. PMID 10037797.
6. Élez, E.; Kocáková, I.; Höhler, T.; Martens, U. M.; Bokemeyer, C.; Van Cutsem, E.; Melichar, B.; Smakal, M.; Csőszi, T.; Topuzov, E.; Orlova, R.; Tjulandin, S.; Rivera, F.; Straub, J.; Bruns, R.; Quaratino, S.; Tabernero, J. (2015). "Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients withKRASwild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial". Annals of Oncology. 26 (1): 132–140. doi:10.1093/annonc/mdu474. ISSN 0923-7534.

Further reading

• Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. doi:10.1016/S1357-2725(96)00155-0. PMID 9251239.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
• Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia. 4 (3): 191–4. doi:10.1038/sj/neo/7900224. PMC 1531692. PMID 11988838.
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. doi:10.2174/0929867053363522. PMID 15638730.
• University of Edinburgh. (2013, November 10). Hope for transplant patients as study finds key to organ scarring. ScienceDaily. Retrieved December 2, 2014 from www.sciencedaily.com/releases/2013/11/131110184408.htm

External links

• CD51 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGAV Info with links in the Cell Migration Gateway