KDM4D

KDM4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Identifiers
Aliases	KDM4D, JMJD2D, lysine demethylase 4D
External IDs	MGI: 3606484 HomoloGene: 69244 GeneCards: KDM4D
Gene ontology Molecular function • oxidoreductase activity • histone demethylase activity (H3-K9 specific) • dioxygenase activity • metal ion binding • histone demethylase activity Cellular component • site of double-strand break • blood microparticle • nucleus • nucleoplasm Biological process • regulation of protein phosphorylation • cellular response to ionizing radiation • regulation of transcription, DNA-templated • positive regulation of chromatin binding • oxidation-reduction process • double-strand break repair via homologous recombination • histone H3-K9 demethylation • transcription, DNA-templated • positive regulation of double-strand break repair via nonhomologous end joining • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55693	244694
Ensembl	ENSG00000186280	ENSMUSG00000053914
UniProt	Q6B0I6	Q3U2K5
RefSeq (mRNA)	NM_018039	NM_173433
RefSeq (protein)	NP_060509.2	NP_775609.2
Location (UCSC)	Chr 11: 94.97 – 95 Mb	Chr 9: 14.46 – 14.5 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Katoh M, Katoh M (May 2004). "Identification and characterization of JMJD2 family genes in silico". Int J Oncol. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
4. "Entrez Gene: JMJD2D jumonji domain containing 2D".

Further reading

• Shin S, Janknecht R (2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.". Biochem. Biophys. Res. Commun. 359 (3): 742–6. doi:10.1016/j.bbrc.2007.05.179. PMID 17555712.
• Whetstine JR, Nottke A, Lan F, et al. (2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.