KLK1

KLK1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK1, KLKR, Klk6, hK1, kallikrein 1
External IDs	HomoloGene: 110727 GeneCards: KLK1
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • extracellular exosome • nucleus Biological process • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3816	n/a
Ensembl	ENSG00000167748	n/a
UniProt	P06870	n/a
RefSeq (mRNA)	NM_002257	n/a
RefSeq (protein)	NP_002248.1	n/a
Location (UCSC)	Chr 19: 50.82 – 50.82 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.^[2][3][4] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.^[5]

References

1. "Human PubMed Reference:".
2. Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
3. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
4. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
5. "Entrez Gene: KLK1 kallikrein 1".

Further reading

• Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.". Biol. Chem. 382 (1): 5–14. doi:10.1515/BC.2001.002. PMID 11258672.
• Lottspeich F, Geiger R, Henschen A, Kutzbach C (1980). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases.". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1947–50. PMID 393608.
• Riegman PH, Vlietstra RJ, Suurmeijer L, et al. (1992). "Characterization of the human kallikrein locus.". Genomics. 14 (1): 6–11. doi:10.1016/S0888-7543(05)80275-7. PMID 1385301.
• Henttu P, Lukkarinen O, Vihko P (1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate.". Int. J. Cancer. 45 (4): 654–60. doi:10.1002/ijc.2910450414. PMID 1691151.
• Qin H, Kemp J, Yip MY, et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization.". Hum. Hered. 41 (4): 222–6. doi:10.1159/000154005. PMID 1783409.
• Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation.". Int. J. Pept. Protein Res. 33 (4): 237–49. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID 2666327.
• Angermann A, Bergmann C, Appelhans H (1990). "Cloning and expression of human salivary-gland kallikrein in Escherichia coli.". Biochem. J. 262 (3): 787–93. PMC 1133342. PMID 2686621.
• Evans BA, Yun ZX, Close JA, et al. (1988). "Structure and chromosomal localization of the human renal kallikrein gene.". Biochemistry. 27 (9): 3124–9. doi:10.1021/bi00409a003. PMID 2898948.
• Fukushima D, Kitamura N, Nakanishi S (1986). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein.". Biochemistry. 24 (27): 8037–43. doi:10.1021/bi00348a030. PMID 3004571.
• Kellermann J, Lottspeich F, Geiger R, Deutzmann R (1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites.". Protein Seq. Data Anal. 1 (3): 177–82. PMID 3163150.
• Takahashi S, Irie A, Katayama Y, et al. (1986). "N-terminal amino acid sequence of human urinary prokallikrein.". J. Biochem. 99 (3): 989–92. PMID 3635530.
• Baker AR, Shine J (1986). "Human kidney kallikrein: cDNA cloning and sequence analysis.". DNA. 4 (6): 445–50. doi:10.1089/dna.1985.4.445. PMID 3853975.
• Del Nery E, Chagas JR, Juliano MA, et al. (1996). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.". Biochem. J. 312 (1): 233–8. PMC 1136249. PMID 7492318.
• Chen LM, Richards GP, Chao L, Chao J (1995). "Molecular cloning, purification and in situ localization of human colon kallikrein.". Biochem. J. 307 (2): 481–6. PMC 1136673. PMID 7733886.
• Clements J, Mukhtar A, Ehrlich A, Yap B (1995). "Glandular kallikrein gene expression in the human uterus.". Braz. J. Med. Biol. Res. 27 (8): 1855–63. PMID 7749374.
• Lin FK, Lin CH, Chou CC, et al. (1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes.". Biochim. Biophys. Acta. 1173 (3): 325–8. doi:10.1016/0167-4781(93)90131-v. PMID 7916636.
• Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.". Can. J. Physiol. Pharmacol. 75 (6): 757–61. doi:10.1139/cjpp-75-6-757. PMID 9276160.
• Bourgeois L, Brillard-Bourdet M, Deperthes D, et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.". J. Biol. Chem. 272 (47): 29590–5. doi:10.1074/jbc.272.47.29590. PMID 9368023.
• Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis.". Biochim. Biophys. Acta. 1479 (1–2): 237–46. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.160