Plasminogen activator

Fibrinolysis

A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.

Types include:

• Tissue plasminogen activator
• Urokinase

It is inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2.

PLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4CIK, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Aliases	PLG, Plasmin
External IDs	MGI: 97620 HomoloGene: 55452 GeneCards: PLG
Targeted by Drug
aminocaproic acid[1]
Gene ontology Molecular function • apolipoprotein binding • protein domain specific binding • peptidase activity • protein binding • serine-type peptidase activity • receptor binding • serine-type endopeptidase activity • hydrolase activity Cellular component • blood microparticle • plasma membrane • extracellular fluid • extracellular region • cell surface • extrinsic component of external side of plasma membrane • extracellular exosome • platelet alpha granule lumen Biological process • hemostasis • negative regulation of cell-substrate adhesion • cellular protein metabolic process • negative regulation of fibrinolysis • fibrinolysis • negative regulation of cell-cell adhesion mediated by cadherin • platelet degranulation • extracellular matrix disassembly • proteolysis • positive regulation of fibrinolysis • tissue remodeling • negative regulation of cell proliferation • blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5340	18815
Ensembl	ENSG00000122194	ENSMUSG00000059481
UniProt	P00747	P20918
RefSeq (mRNA)	NM_001168338 NM_000301	NM_008877
RefSeq (protein)	NP_000292.1	NP_032903.3
Location (UCSC)	Chr 6: 160.7 – 160.75 Mb	Chr 17: 12.38 – 12.42 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

1. "Drugs that physically interact with Plasminogen view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".