LEFTY2

LEFTY2
Identifiers
Aliases LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs MGI: 2443573 HomoloGene: 2434 GeneCards: LEFTY2
Orthologs
Species Human Mouse
Entrez

7044

320202

Ensembl

ENSG00000143768

ENSMUSG00000066652

UniProt

O00292

P57785

RefSeq (mRNA)

NM_001172425
NM_003240

NM_177099

RefSeq (protein)

NP_001165896.1
NP_003231.2

NP_796073.1

Location (UCSC) Chr 1: 225.94 – 225.94 Mb Chr 1: 180.89 – 180.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene. [3]

Function

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Left-right determination factor 2". Retrieved 2016-04-19.

Further reading

  • Tabibzadeh S, Kothapalli R, Buyuksal I (1997). "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. doi:10.2741/a158. PMID 9230066. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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