Macavirus
| Macavirus | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Order: | Herpesvirales |
| Family: | Herpesviridae |
| Subfamily: | Gammaherpesvirinae |
| Genus: | Macavirus |
| Type Species | |
Macavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are currently nine species in this genus including the type species Alcelaphine herpesvirus 1. Diseases associated with this genus include: inapparent infection in their reservoir hosts (wildebeest for alHV-1 and sheep for ovHV-2), but fatal lymphoproliferative disease when they infect MCF-susceptible hosts, including cattle, deer, bison, water buffalo and pigs.[1][2]
Taxonomy
Group: dsDNA
- Family: Herpesviridae
- Sub-Family: Gammaherpesvirinae
- Genus: Macavirus
- Alcelaphine herpesvirus 1
- Alcelaphine herpesvirus 2
- Bovine herpesvirus 6
- Caprine herpesvirus 2
- Hippotragine herpesvirus 1
- Ovine herpesvirus 2
- Suid herpesvirus 3
- Suid herpesvirus 4
- Suid herpesvirus 5
Structure
Viruses in Macavirus are enveloped, with icosahedral, Spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 180kb in length.[1]
| Genus | Structure | Symmetry | Capsid | Genomic Arrangement | Genomic Segmentation |
|---|---|---|---|---|---|
| Macavirus | Spherical Pleomorphic | T=16 | Enveloped | Linear | Monopartite |
Life Cycle
Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. Dna templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Mammals serve as the natural host.[1]
| Genus | Host Details | Tissue Tropism | Entry Details | Release Details | Replication Site | Assembly Site | Transmission |
|---|---|---|---|---|---|---|---|
| Macavirus | Mammals | B-lymphocytes | Glycoprotiens | Budding | Nucleus | Nucleus | Sex; saliva |
References
- 1 2 3 "Viral Zone". ExPASy. Retrieved 15 June 2015.
- 1 2 ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.