PYCR1

PYCR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1
External IDs MGI: 2384795 HomoloGene: 56002 GeneCards: PYCR1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5831

209027

Ensembl

ENSG00000183010

ENSMUSG00000025140

UniProt

P32322

Q922W5

RefSeq (mRNA)

NM_001282279
NM_001282280
NM_001282281
NM_006907
NM_153824

NM_144795

RefSeq (protein)

NP_001269209.1
NP_001269210.1
NP_008838.2
NP_722546.1

NP_659044.1

Location (UCSC) Chr 17: 81.93 – 81.94 Mb Chr 11: 120.64 – 120.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.[3][4]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Dougherty KM, Brandriss MC, Valle D (Feb 1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J Biol Chem. 267 (2): 871–5. PMID 1730675.
  4. 1 2 "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1".

Further reading


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