PYCR1

PYCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GER, 2GR9, 2GRA, 2IZZ
Identifiers
Aliases	PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1
External IDs	MGI: 2384795 HomoloGene: 56002 GeneCards: PYCR1
Gene ontology Molecular function • oxidoreductase activity • protein binding • pyrroline-5-carboxylate reductase activity • identical protein binding Cellular component • mitochondrial matrix • mitochondrion Biological process • regulation of mitochondrial membrane potential • cellular response to oxidative stress • negative regulation of hydrogen peroxide-induced cell death • cellular amino acid biosynthetic process • oxidation-reduction process • L-proline biosynthetic process • proline biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5831	209027
Ensembl	ENSG00000183010	ENSMUSG00000025140
UniProt	P32322	Q922W5
RefSeq (mRNA)	NM_001282279 NM_001282280 NM_001282281 NM_006907 NM_153824	NM_144795
RefSeq (protein)	NP_001269209.1 NP_001269210.1 NP_008838.2 NP_722546.1	NP_659044.1
Location (UCSC)	Chr 17: 81.93 – 81.94 Mb	Chr 11: 120.64 – 120.64 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.^[3][4]

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dougherty KM, Brandriss MC, Valle D (Feb 1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J Biol Chem. 267 (2): 871–5. PMID 1730675.
4. "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1".

Further reading

• Herzfeld A, Legg MA, Greengard O (1978). "Human colon tumors: enzymic and histological characteristics". Cancer. 42 (3): 1280–3. doi:10.1002/1097-0142(197809)42:3<1280::AID-CNCR2820420337>3.0.CO;2-P. PMID 212173.
• Merrill MJ, Yeh GC, Phang JM (1989). "Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH". J. Biol. Chem. 264 (16): 9352–8. PMID 2722838.
• Yeh GC, Roth EF, Phang JM, et al. (1984). "The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects". J. Biol. Chem. 259 (9): 5454–8. PMID 6201483.
• Herzfeld A, Greengard O (1981). "Enzyme activities in human fetal and neoplastic tissues". Cancer. 46 (9): 2047–54. doi:10.1002/1097-0142(19801101)46:9<2047::AID-CNCR2820460924>3.0.CO;2-Q. PMID 6253048.
• Yeh GC, Harris SC, Phang JM (1981). "Pyrroline-5-carboxylate reductase in human erythrocytes". J. Clin. Invest. 67 (4): 1042–6. doi:10.1172/JCI110115. PMC 370662. PMID 6894153.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Basch JJ, Wickham ED, Farrell HM (1997). "Pyrroline-5-carboxylate reductase in lactating bovine mammary glands". J. Dairy Sci. 79 (8): 1361–8. doi:10.3168/jds.S0022-0302(96)76493-7. PMID 8880459.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meng Z, Lou Z, Liu Z, et al. (2006). "Crystal structure of human pyrroline-5-carboxylate reductase". J. Mol. Biol. 359 (5): 1364–77. doi:10.1016/j.jmb.2006.04.053. PMID 16730026.