Protein-Npi-phosphohistidine-sugar phosphotransferase

Thus, the two substrates of this enzyme are protein Npi-phospho-L-histidine and sugar, whereas its two products are protein histidine and sugar phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is protein-Npi-phosphohistidine:sugar Npi-phosphotransferase. Other names in common use include glucose permease, PTS permease, phosphotransferase, phosphohistidinoprotein-hexose, enzyme IIl4ac, gene glC proteins, gene bglC RNA formation factors, PEP-dependent phosphotransferase enzyme II, PEP-sugar phosphotransferase enzyme II, phosphoenolpyruvate-sugar phosphotransferase enzyme II, phosphohistidinoprotein-hexose phosphotransferase, phosphohistidinoprotein-hexose phosphoribosyltransferase, phosphoprotein factor-hexose phosophotransferase, protein, specific or class, gene bglC, ribonucleic acid formation factor, gene glC, sucrose phosphotransferase system II, and protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase. This enzyme participates in 7 metabolic pathways: glycolysis / gluconeogenesis, fructose and mannose metabolism, galactose metabolism, ascorbate and aldarate metabolism, starch and sucrose metabolism, aminosugars metabolism, and phosphotransferase system (pts).

Structural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes 1A3A, 1A6J, 1AX3, 1BLE, 1E2A, 1E2B, 1F3Z, 1GGR, 1GLA, 1GLB, 1GLC, 1GLD, 1GLE, 1GPR, 1H9C, 1IBA, 1IIB, 1NRZ, 1O2F, 1O53, 1PDO, 1TVM, 1VRC, 1WCR, 2A0J, 2E2A, 2F3G, 2FEW, and 2GPR.

References

Kornberg HL, Riordan C (1976). "Uptake of galactose into Escherichia coli by facilitated diffusion". J. Gen. Microbiol. 94 (1): 75–89. doi:10.1099/00221287-94-1-75. PMID 778334.
"The bacterial phosphoenolpyruvate: sugar phosphotransferase system". Biochim. Biophys. Acta. 457 (3-4): 213–57. 1976. doi:10.1016/0304-4157(76)90001-0. PMID 187249.

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I II III IV V RNA-directed DNA polymerase Reverse transcriptase Telomerase DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase RNA polymerase I RNA polymerase II RNA polymerase III RNA polymerase IV Primase RNA-dependent RNA polymerase PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases

2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases

2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.