TSPAN4

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
Gene ontology Molecular function • antigen binding • integrin binding • protein binding Cellular component • integral component of membrane • vesicle • plasma membrane • integral component of plasma membrane • membrane • focal adhesion Biological process • cell surface receptor signaling pathway • protein complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7106	64540
Ensembl	ENSG00000214063	ENSMUSG00000025511
UniProt	O14817	Q9DCK3
RefSeq (mRNA)	NM_001025234 NM_001025235 NM_001025236 NM_001025237 NM_001025238 NM_001025239 NM_003271	NM_001252588 NM_053082
RefSeq (protein)	NP_001020405.1 NP_001020406.1 NP_001020407.1 NP_001020408.1 NP_001020409.1 NP_001020410.1 NP_003262.1	NP_001239517.1 NP_444312.1
Location (UCSC)	Chr 11: 0.84 – 0.87 Mb	Chr 7: 141.48 – 141.49 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[3][4]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[4]

Interactions

TSPAN4 has been shown to interact with CD9,^[3] ITGA6,^[3] CD29,^[3] CD49c^[3] and CD81.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
4. "Entrez Gene: TSPAN4 tetraspanin 4".

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
• Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family.". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
• Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
• Yauch RL, Kazarov AR, Desai B, et al. (2000). "Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151.". J. Biol. Chem. 275 (13): 9230–8. doi:10.1074/jbc.275.13.9230. PMID 10734060.
• Lozahic S, Christiansen D, Manié S, et al. (2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.