Tyrosine-protein kinase BLK

BLK
Identifiers
Aliases	BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDs	MGI: 88169 HomoloGene: 1297 GeneCards: BLK
Genetically Related Diseases
smallpox, rheumatoid arthritis, systemic lupus erythematosus[1]
Targeted by Drug
ibrutinib[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding Cellular component • membrane • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane Biological process • B cell receptor signaling pathway • cell differentiation • intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of apoptotic process • protein phosphorylation • regulation of cell proliferation • regulation of podosome assembly • peptidyl-tyrosine autophosphorylation • regulation of phagocytosis • innate immune response • positive regulation of insulin secretion • cytoskeleton organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	640	12143
Ensembl	ENSG00000136573	ENSMUSG00000014453
UniProt	P51451	P16277
RefSeq (mRNA)	NM_001715	NM_007549
RefSeq (protein)	NP_001706.2	NP_031575.2
Location (UCSC)	Chr 8: 11.49 – 11.56 Mb	Chr 14: 63.37 – 63.42 Mb
PubMed search	[3]	[4]
Wikidata

View/Edit Human

View/Edit Mouse

Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene.^[5][6]

Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.^[7]

References

1. "Diseases that are genetically associated with BLK view/edit references on wikidata".
2. "Drugs that physically interact with Tyrosine-protein kinase Blk view/edit references on wikidata".
3. "Human PubMed Reference:".
4. "Mouse PubMed Reference:".
5. Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
6. "Entrez Gene: BLK B lymphoid tyrosine kinase".
7. Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.

Further reading

• Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.". Science. 247 (4940): 332–6. doi:10.1126/science.2404338. PMID 2404338.
• Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters.". J. Biol. Chem. 270 (43): 25968–75. doi:10.1074/jbc.270.43.25968. PMID 7592787.
• Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.
• Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.". J. Immunol. 154 (3): 1265–72. PMID 7822795.
• Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.". J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.
• Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.". Mol. Cell. Biol. 13 (9): 5877–87. PMC 360336. PMID 8395016.
• Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.". J. Biol. Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124.
• Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMC 231474. PMID 8756631.
• Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi:10.1006/bbrc.1997.6638. PMID 9177269.
• Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.". J. Biol. Chem. 273 (14): 7783–6. doi:10.1074/jbc.273.14.7783. PMID 9525867.
• Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
• Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
• Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.". Cancer Lett. 188 (1-2): 121–6. doi:10.1016/S0304-3835(02)00055-1. PMID 12406557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.