Bone morphogenetic protein 5

BMP5
Identifiers
Aliases	BMP5, entrez:653
External IDs	OMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5
Gene ontology Molecular function • cytokine activity • BMP receptor binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • cellular component • extracellular space • extracellular region • membrane-bounded vesicle Biological process • regulation of apoptotic process • pattern specification process • skeletal system development • cell differentiation • male genitalia development • regulation of MAPK cascade • SMAD protein signal transduction • ossification • positive regulation of epithelial cell proliferation • negative regulation of mononuclear cell migration • negative regulation of cortisol biosynthetic process • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of dendrite development • positive regulation of DNA-dependent DNA replication • BMP signaling pathway • multicellular organism development • growth • cartilage development • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of insulin-like growth factor receptor signaling pathway • type B pancreatic cell development • negative regulation of steroid biosynthetic process • negative regulation of epithelial to mesenchymal transition • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of aldosterone biosynthetic process • heart trabecula morphogenesis • pericardium morphogenesis • hindbrain development • cardiac septum morphogenesis • endocardial cushion formation • neural fold elevation formation • pharyngeal system development • cardiac muscle tissue development • chorio-allantoic fusion • allantois development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	653	12160
Ensembl	ENSG00000112175	ENSMUSG00000032179
UniProt	P22003	P49003
RefSeq (mRNA)	NM_021073	NM_007555
RefSeq (protein)	NP_066551.1 NP_066551.1	NP_031581.2
Location (UCSC)	Chr 6: 55.75 – 55.88 Mb	Chr 9: 75.78 – 75.9 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.^[3][4][5]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
4. Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.
5. "Entrez Gene: BMP5 bone morphogenetic protein 5".

Further reading

• Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America. 87 (24): 9843–7. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636.
• Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.
• You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science. 40 (2): 296–311. PMID 9950587.
• Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221.
• Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
• Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867.
• Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science. 115 (Pt 4): 753–60. PMID 11865031.
• Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (May 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953.
• Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision. 8: 241–50. PMID 12131877.
• Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development. 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.
• Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325.
• Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal. 46 (3): 389–96. PMID 15861517.
• Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy. 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506.
• Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). "Extreme context specificity in differential allelic expression". Human Molecular Genetics. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.