Pneumonia

Pneumonia
pneumonitis, bronchopneumonia[1]
A chest X-ray showing a very prominent wedge-shape area of airspace consolidation in the right lung characteristic of bacterial pneumonia.
Pronunciation	/njuːˈmoʊ.ni.ə/
Specialty	Infectious disease, pulmonology
Symptoms	cough, difficulty breathing, rapid breathing, fever
Duration	few weeks
Causes	bacteria, virus, aspiration
Differential diagnosis	COPD, asthma, pulmonary edema, pulmonary embolism
Medication	antibiotics, steroids, antivirals
Frequency	450 million (7%) per year
Deaths	4 million per year

Pneumonia is an inflammatory condition of the lung affecting primarily the microscopic air sacs known as alveoli.^[2][3] Typical signs and symptoms include a varying severity and combination of productive or dry cough, chest pain, fever, and trouble breathing, depending on the underlying cause.^[4]

Pneumonia is usually caused by infection with viruses or bacteria and less commonly by other microorganisms, certain medications and conditions such as autoimmune diseases.^[2][5] Risk factors include other lung diseases such as cystic fibrosis, COPD, and asthma, diabetes, heart failure, a history of smoking, a poor ability to cough such as following a stroke, or a weak immune system.^[6] Diagnosis is often based on the symptoms and physical examination. Chest X-ray, blood tests, and culture of the sputum may help confirm the diagnosis.^[7] The disease may be classified by where it was acquired with community, hospital, or health care associated pneumonia.^[8]

Vaccines to prevent certain types of pneumonia are available. Other methods of prevention include handwashing and not smoking.^[9] Treatment depends on the underlying cause.^[10] Pneumonia believed to be due to bacteria is treated with antibiotics.^[11] If the pneumonia is severe, the affected person is generally hospitalized.^[10] Oxygen therapy may be used if oxygen levels are low.^[11]

Pneumonia affects approximately 450 million people globally (7% of the population) and results in about 4 million deaths per year.^[12][13] Pneumonia was regarded by William Osler in the 19th century as "the captain of the men of death".^[14] With the introduction of antibiotics and vaccines in the 20th century, survival improved.^[12] Nevertheless, in developing countries, and among the very old, the very young, and the chronically ill, pneumonia remains a leading cause of death.^[12][15] Pneumonia often shortens suffering among those already close to death and has thus been called "the old man's friend".^[16]

A video explanation of pneumonia

Signs and symptoms

Symptoms frequency[17]
Symptom	Frequency
Cough	79–91%
Fatigue	90%
Fever	71–75%
Shortness of breath	67–75%
Sputum	60–65%
Chest pain	39–49%

Main symptoms of infectious pneumonia

People with infectious pneumonia often have a productive cough, fever accompanied by shaking chills, shortness of breath, sharp or stabbing chest pain during deep breaths, and an increased rate of breathing.^[18] In the elderly, confusion may be the most prominent sign.^[18]

The typical signs and symptoms in children under five are fever, cough, and fast or difficult breathing.^[19] Fever is not very specific, as it occurs in many other common illnesses, may be absent in those with severe disease, malnutrition or in the elderly. In addition, a cough is frequently absent in children less than 2 months old.^[19] More severe signs and symptoms in children may include blue-tinged skin, unwillingness to drink, convulsions, ongoing vomiting, extremes of temperature, or a decreased level of consciousness.^[19][20]

Bacterial and viral cases of pneumonia usually present with similar symptoms.^[21] Some causes are associated with classic, but non-specific, clinical characteristics. Pneumonia caused by Legionella may occur with abdominal pain, diarrhea, or confusion,^[22] while pneumonia caused by Streptococcus pneumoniae is associated with rusty colored sputum,^[23] and pneumonia caused by Klebsiella may have bloody sputum often described as "currant jelly".^[17] Bloody sputum (known as hemoptysis) may also occur with tuberculosis, Gram-negative pneumonia, and lung abscesses as well as more commonly with acute bronchitis.^[20] Mycoplasma pneumonia may occur in association with swelling of the lymph nodes in the neck, joint pain, or a middle ear infection.^[20] Viral pneumonia presents more commonly with wheezing than does bacterial pneumonia.^[21] Pneumonia was historically divided into "typical" and "atypical" based on the belief that the presentation predicted the underlying cause.^[24] However, evidence has not supported this distinction, thus it is no longer emphasized.^[24]

Cause

The bacterium Streptococcus pneumoniae, a common cause of pneumonia, imaged by an electron microscope

Pneumonia is due to infections caused primarily by bacteria or viruses and less commonly by fungi and parasites. Although there are more than 100 strains of infectious agents identified, only a few are responsible for the majority of the cases. Mixed infections with both viruses and bacteria may occur in up to 45% of infections in children and 15% of infections in adults.^[12] A causative agent may not be isolated in approximately half of cases despite careful testing.^[16]

The term pneumonia is sometimes more broadly applied to any condition resulting in inflammation of the lungs (caused for example by autoimmune diseases, chemical burns or drug reactions); however, this inflammation is more accurately referred to as pneumonitis.^[25][26]

Conditions and risk factors that predispose to pneumonia include smoking, immunodeficiency, alcoholism, chronic obstructive pulmonary disease, asthma, chronic kidney disease, and liver disease.^[20][27] The use of acid-suppressing medications—such as proton-pump inhibitors or H2 blockers—is associated with an increased risk of pneumonia.^[28] The risk is also increased in old age.^[20]

Bacteria

Cavitating pneumonia as seen on CT. Pneumonia due to MRSA

Bacteria are the most common cause of community-acquired pneumonia (CAP), with Streptococcus pneumoniae isolated in nearly 50% of cases.^[29][30] Other commonly isolated bacteria include Haemophilus influenzae in 20%, Chlamydophila pneumoniae in 13%, and Mycoplasma pneumoniae in 3% of cases;^[29] Staphylococcus aureus; Moraxella catarrhalis; Legionella pneumophila and Gram-negative bacilli.^[16] A number of drug-resistant versions of the above infections are becoming more common, including drug-resistant Streptococcus pneumoniae (DRSP) and methicillin-resistant Staphylococcus aureus (MRSA).^[20]

The spreading of organisms is facilitated when risk factors are present.^[16] Alcoholism is associated with Streptococcus pneumoniae, anaerobic organisms, and Mycobacterium tuberculosis; smoking facilitates the effects of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Legionella pneumophila. Exposure to birds is associated with Chlamydia psittaci; farm animals with Coxiella burnetti; aspiration of stomach contents with anaerobic organisms; and cystic fibrosis with Pseudomonas aeruginosa and Staphylococcus aureus.^[16] Streptococcus pneumoniae is more common in the winter,^[16] and should be suspected in persons aspirating a large amount anaerobic organisms.^[20]

Viruses

In adults, viruses account for approximately a third^[12] and in children for about 15% of pneumonia cases.^[31] Commonly implicated agents include rhinoviruses, coronaviruses, influenza virus, respiratory syncytial virus (RSV), adenovirus, and parainfluenza.^[12][32] Herpes simplex virus rarely causes pneumonia, except in groups such as: newborns, persons with cancer, transplant recipients, and people with significant burns.^[33] People following organ transplantation or those otherwise-immunocompromised present high rates of cytomegalovirus pneumonia.^[31][33] Those with viral infections may be secondarily infected with the bacteria Streptococcus pneumoniae, Staphylococcus aureus, or Haemophilus influenzae, particularly when other health problems are present.^[20][31] Different viruses predominate at different periods of the year; during influenza season, for example, influenza may account for over half of all viral cases.^[31] Outbreaks of other viruses also occasionally occur, including hantaviruses and coronavirus.^[31]

Fungi

Fungal pneumonia is uncommon, but occurs more commonly in individuals with weakened immune systems due to AIDS, immunosuppressive drugs, or other medical problems.^[16][34] It is most often caused by Histoplasma capsulatum, blastomyces, Cryptococcus neoformans, Pneumocystis jiroveci (pneumocystis pneumonia), and Coccidioides immitis. Histoplasmosis is most common in the Mississippi River basin, and coccidioidomycosis is most common in the Southwestern United States.^[16] The number of cases has been increasing in the later half of the 20th century due to increasing travel and rates of immunosuppression in the population.^[34]

Parasites

A variety of parasites can affect the lungs, including Toxoplasma gondii, Strongyloides stercoralis, Ascaris lumbricoides, and Plasmodium malariae.^[35] These organisms typically enter the body through direct contact with the skin, ingestion, or via an insect vector.^[35] Except for Paragonimus westermani, most parasites do not affect specifically the lungs but involve the lungs secondarily to other sites.^[35] Some parasites, in particular those belonging to the Ascaris and Strongyloides genera, stimulate a strong eosinophilic reaction, which may result in eosinophilic pneumonia.^[35] In other infections, such as malaria, lung involvement is due primarily to cytokine-induced systemic inflammation.^[35] In the developed world these infections are most common in people returning from travel or in immigrants.^[35] Around the world, these infections are most common in the immunodeficient.^[36]

Noninfectious

Idiopathic interstitial pneumonia or noninfectious pneumonia^[37] is a class of diffuse lung diseases. They include diffuse alveolar damage, organizing pneumonia, nonspecific interstitial pneumonia, lymphocytic interstitial pneumonia, desquamative interstitial pneumonia, respiratory bronchiolitis interstitial lung disease, and usual interstitial pneumonia.^[38]

Mechanisms

Pneumonia fills the lung's alveoli with fluid, hindering oxygenation. The alveolus on the left is normal, whereas the one on the right is full of fluid from pneumonia.

Pneumonia frequently starts as an upper respiratory tract infection that moves into the lower respiratory tract.^[39] It is pneumonitis (lung inflammation) combined with consolidation (liquid in spaces normally inflated with air).^[40]

Viral

Viruses may reach the lung by a number of different routes. Respiratory syncytial virus is typically contracted when people touch contaminated objects and then they touch their eyes or nose.^[31] Other viral infections occur when contaminated airborne droplets are inhaled through the mouth or nose.^[20] Once in the upper airway, the viruses may make their way in the lungs, where they invade the cells lining the airways, alveoli, or lung parenchyma.^[31] Some viruses such as measles and herpes simplex may reach the lungs via the blood.^[41] The invasion of the lungs may lead to varying degrees of cell death.^[31] When the immune system responds to the infection, even more lung damage may occur.^[31] Primarily white blood cells, mainly mononuclear cells, generate the inflammation.^[41] As well as damaging the lungs, many viruses simultaneously affect other organs and thus disrupt other body functions. Viruses also make the body more susceptible to bacterial infections; in this way, bacterial pneumonia can arise as a co-morbid condition.^[32]

Bacterial

Most bacteria enter the lungs via small aspirations of organisms residing in the throat or nose.^[20] Half of normal people have these small aspirations during sleep.^[24] While the throat always contains bacteria, potentially infectious ones reside there only at certain times and under certain conditions.^[24] A minority of types of bacteria such as Mycobacterium tuberculosis and Legionella pneumophila reach the lungs via contaminated airborne droplets.^[20] Bacteria can spread also via the blood.^[21] Once in the lungs, bacteria may invade the spaces between cells and between alveoli, where the macrophages and neutrophils (defensive white blood cells) attempt to inactivate the bacteria.^[42] The neutrophils also release cytokines, causing a general activation of the immune system.^[43] This leads to the fever, chills, and fatigue common in bacterial pneumonia.^[43] The neutrophils, bacteria, and fluid from surrounding blood vessels fill the alveoli, resulting in the consolidation seen on chest X-ray.^[44]

Diagnosis

	Crackles Crackles heard in the lungs of a person with pneumonia using a stethoscope.
Problems playing this file? See media help.

Pneumonia is typically diagnosed based on a combination of physical signs and a chest X-ray.^[45] However, the underlying cause can be difficult to confirm, as there is no definitive test able to distinguish between bacterial and non-bacterial origin.^[12][45] The World Health Organization has defined pneumonia in children clinically based on either a cough or difficulty breathing and a rapid respiratory rate, chest indrawing, or a decreased level of consciousness.^[46] A rapid respiratory rate is defined as greater than 60 breaths per minute in children under 2 months old, 50 breaths per minute in children 2 months to 1 year old, or greater than 40 breaths per minute in children 1 to 5 years old.^[46] In children, increased respiratory rate and lower chest indrawing are more sensitive than hearing chest crackles with a stethoscope.^[19] Grunting and nasal flaring may be other useful signs in children less than five.^[47]

In general, in adults, investigations are not needed in mild cases.^[48] There is a very low risk of pneumonia if all vital signs and auscultation are normal.^[49] In persons requiring hospitalization, pulse oximetry, chest radiography and blood tests—including a complete blood count, serum electrolytes, C-reactive protein level, and possibly liver function tests—are recommended.^[48] The diagnosis of influenza-like illness can be made based on the signs and symptoms; however, confirmation of an influenza infection requires testing.^[50] Thus, treatment is frequently based on the presence of influenza in the community or a rapid influenza test.^[50]

Physical exam

Physical examination may sometimes reveal low blood pressure, high heart rate, or low oxygen saturation.^[20] The respiratory rate may be faster than normal, and this may occur a day or two before other signs.^[20][24] Examination of the chest may be normal, but it may show decreased chest expansion on the affected side. Harsh breath sounds from the larger airways that are transmitted through the inflamed lung are termed bronchial breathing and are heard on auscultation with a stethoscope.^[20] Crackles (rales) may be heard over the affected area during inspiration.^[20] Percussion may be dulled over the affected lung, and increased, rather than decreased, vocal resonance distinguishes pneumonia from a pleural effusion.^[18]

Imaging

Right middle lobe pneumonia in a child as seen on plain X ray

CT of the chest demonstrating right-side pneumonia (left side of the image)

A chest radiograph is frequently used in diagnosis.^[19] In people with mild disease, imaging is needed only in those with potential complications, those not having improved with treatment, or those in which the cause is uncertain.^[19][48] If a person is sufficiently sick to require hospitalization, a chest radiograph is recommended.^[48] Findings do not always match the severity of disease and do not reliably separate between bacterial infection and viral infection.^[19]

X-ray presentations of pneumonia may be classified as lobar pneumonia, bronchopneumonia (also known as lobular pneumonia), and interstitial pneumonia.^[51] Bacterial, community-acquired pneumonia classically show lung consolidation of one lung segmental lobe, which is known as lobar pneumonia.^[29] However, findings may vary, and other patterns are common in other types of pneumonia.^[29] Aspiration pneumonia may present with bilateral opacities primarily in the bases of the lungs and on the right side.^[29] Radiographs of viral pneumonia may appear normal, appear hyper-inflated, have bilateral patchy areas, or present similar to bacterial pneumonia with lobar consolidation.^[29] Radiologic findings may not be present in the early stages of the disease, especially in the presence of dehydration, or may be difficult to be interpreted in the obese or those with a history of lung disease.^[20] A CT scan can give additional information in indeterminate cases.^[29]

Microbiology

In patients managed in the community, determining the causative agent is not cost-effective and typically does not alter management.^[19] For people that do not respond to treatment, sputum culture should be considered, and culture for Mycobacterium tuberculosis should be carried out in persons with a chronic productive cough.^[48] Testing for other specific organisms may be recommended during outbreaks, for public health reasons.^[48] In those hospitalized for severe disease, both sputum and blood cultures are recommended,^[48] as well as testing the urine for antigens to Legionella and Streptococcus.^[52] Viral infections can be confirmed via detection of either the virus or its antigens with culture or polymerase chain reaction (PCR), among other techniques.^[12] The causative agent is determined in only 15% of cases with routine microbiological tests.^[18]

Classification

Pneumonitis refers to lung inflammation; pneumonia refers to pneumonitis, usually due to infection but sometimes non-infectious, that has the additional feature of pulmonary consolidation.^[53] Pneumonia is most commonly classified by where or how it was acquired: community-acquired, aspiration, healthcare-associated, hospital-acquired, and ventilator-associated pneumonia.^[29] It may also be classified by the area of lung affected: lobar pneumonia, bronchial pneumonia and acute interstitial pneumonia;^[29] or by the causative organism.^[54] Pneumonia in children may additionally be classified based on signs and symptoms as non-severe, severe, or very severe.^[55]

The setting in which pneumonia develops is important to treatment,^[56][57] as it correlates to which pathogens are likely suspects,^[56] which mechanisms are likely, which antibiotics are likely to work or fail,^[56] and which complications can be expected based on the person's health status.

Community

Community-acquired pneumonia (CAP) is acquired in the community,^[56][57] outside of health care facilities. Compared with health care–associated pneumonia, it is less likely to involve multidrug-resistant bacteria. Although the latter are no longer rare in CAP,^[56] they are still less likely.

Healthcare

Health care–associated pneumonia (HCAP) is an infection associated with recent exposure to the health care system,^[56] including hospital, outpatient clinic, nursing home, dialysis center, chemotherapy treatment, or home care.^[57]

HCAP is sometimes called MCAP (medical care–associated pneumonia).

Hospital

Hospital-acquired pneumonia is acquired in a hospital^[56] (specifically, pneumonia that occurs 48 hours or more after admission, which was not incubating at the time of admission^[57]), and as such is likely to involve hospital-acquired infections, with higher risk of multidrug-resistant pathogens. Also, because hospital patients are often ill (which is why they are present in the hospital), comorbidities are an issue.

Ventilator

Ventilator-associated pneumonia occurs in people breathing with the help of mechanical ventilation^[56] (specifically, it is pneumonia that arises more than 48 to 72 hours after endotracheal intubation^[57]). Like any medical device, ventilators involve some risk of infection because of how difficult it is to prevent bacteria from colonizing the internal parts and surfaces, even with diligent cleaning. People who need ventilators typically are rather ill, to begin with, so a superimposed pneumonia is not always easily managed. Immunodeficiency may be involved because of poor nutritional status and whichever disorders are comorbid.

Differential diagnosis

Several diseases can present with similar signs and symptoms to pneumonia, such as: chronic obstructive pulmonary disease (COPD), asthma, pulmonary edema, bronchiectasis, lung cancer, and pulmonary emboli.^[18] Unlike pneumonia, asthma and COPD typically present with wheezing, pulmonary edema presents with an abnormal electrocardiogram, cancer and bronchiectasis present with a cough of longer duration, and pulmonary emboli presents with acute onset sharp chest pain and shortness of breath.^[18]

Prevention

Prevention includes vaccination, environmental measures and appropriate treatment of other health problems.^[19] It is believed that, if appropriate preventive measures were instituted globally, mortality among children could be reduced by 400,000; and, if proper treatment were universally available, childhood deaths could be decreased by another 600,000.^[21]

Vaccination

Vaccination prevents against certain bacterial and viral pneumonias both in children and adults. Influenza vaccines are modestly effective at preventing symptoms of influenza.^[12][58] The Center for Disease Control and Prevention (CDC) recommends yearly vaccination for every person 6 months and older.^[59] Immunizing health care workers decreases the risk of viral pneumonia among their patients.^[52]

Vaccinations against Haemophilus influenzae and Streptococcus pneumoniae have good evidence to support their use.^[39] Vaccinating children against Streptococcus pneumoniae has led to a decreased incidence of these infections in adults, because many adults acquire infections from children. A Streptococcus pneumoniae vaccine is available for adults, and has been found to decrease the risk of invasive pneumococcal disease.^[60] Other vaccines for which there is support for a protective effect against pneumonia include pertussis, varicella, and measles.^[61]

Medications

When influenza outbreaks occur, medications such as amantadine or rimantadine may help prevent the condition; however are associated with side effects.^[62] Zanamivir or oseltamivir decrease the chance that those exposed will develop symptoms; however, it is recommended that potential side effects are taken into account.^[63]

Other

Smoking cessation^[48] and reducing indoor air pollution, such as that from cooking indoors with wood or dung, are both recommended.^[19][21] Smoking appears to be the single biggest risk factor for pneumococcal pneumonia in otherwise-healthy adults.^[52] Hand hygiene and coughing into one's sleeve may also be effective preventative measures.^[61] Wearing surgical masks by the sick may also prevent illness.^[52]

Appropriately treating underlying illnesses (such as HIV/AIDS, diabetes mellitus, and malnutrition) can decrease the risk of pneumonia.^[21][61][64] In children less than 6 months of age, exclusive breast feeding reduces both the risk and severity of disease.^[21] In those with HIV/AIDS and a CD4 count of less than 200 cells/uL the antibiotic trimethoprim/sulfamethoxazole decreases the risk of Pneumocystis pneumonia^[65] and is also useful for prevention in those that are immunocomprised but do not have HIV.^[66]

Testing pregnant women for Group B Streptococcus and Chlamydia trachomatis, and administering antibiotic treatment, if needed, reduces rates of pneumonia in infants;^[67][68] preventive measures for HIV transmission from mother to child may also be efficient.^[69] Suctioning the mouth and throat of infants with meconium-stained amniotic fluid has not been found to reduce the rate of aspiration pneumonia and may cause potential harm,^[70] thus this practice is not recommended in the majority of situations.^[70] In the frail elderly good oral health care may lower the risk of aspiration pneumonia.^[71] Zinc supplementation in children 2 months to five years old appears to reduce rates of pneumonia.^[72]

Management

CURB-65
Symptom	Points
Confusion	1
Urea>7 mmol/l	1
Respiratory rate>30	1
SBP<90mmHg, DBP<60mmHg	1
Age>=65	1

Oral antibiotics, rest, simple analgesics, and fluids usually suffice for complete resolution.^[48] However, those with other medical conditions, the elderly, or those with significant trouble breathing may require more advanced care. If the symptoms worsen, the pneumonia does not improve with home treatment, or complications occur, hospitalization may be required.^[48] Worldwide, approximately 7–13% of cases in children result in hospitalization,^[19] whereas in the developed world between 22 and 42% of adults with community-acquired pneumonia are admitted.^[48] The CURB-65 score is useful for determining the need for admission in adults.^[48] If the score is 0 or 1, people can typically be managed at home; if it is 2, a short hospital stay or close follow-up is needed; if it is 3–5, hospitalization is recommended.^[48] In children those with respiratory distress or oxygen saturations of less than 90% should be hospitalized.^[73] The utility of chest physiotherapy in pneumonia has not yet been determined.^[74] Non-invasive ventilation may be beneficial in those admitted to the intensive care unit.^[75] Over-the-counter cough medicine has not been found to be effective^[76] nor has the use of zinc in children.^[77] There is insufficient evidence for mucolytics.^[76]

Bacterial

Antibiotics improve outcomes in those with bacterial pneumonia.^[13] Antibiotic choice depends initially on the characteristics of the person affected, such as age, underlying health, and the location the infection was acquired. In the UK, treatment before culture results with amoxicillin is recommended as the first line for community-acquired pneumonia, with doxycycline or clarithromycin as alternatives.^[48] In North America, where the "atypical" forms of community-acquired pneumonia are more common, macrolides (such as azithromycin or erythromycin), and doxycycline have displaced amoxicillin as first-line outpatient treatment in adults.^[30][78] In children with mild or moderate symptoms, amoxicillin remains the first line.^[73] The use of fluoroquinolones in uncomplicated cases is discouraged due to concerns about side-effects and generating resistance in light of there being no greater clinical benefit.^[30][79]

For those who require hospitalization and caught their pneumonia in the community the use of a β-lactam such as cephazolin plus macrolide such as azithromycin or a fluoroquinolones is recommended.^[80] The addition of corticosteroids also appears to improve outcomes.^[81][82]

The duration of treatment has traditionally been seven to ten days, but increasing evidence suggests that shorter courses (three to five days) are similarly effective.^[83] Recommended for hospital-acquired pneumonia include third- and fourth-generation cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and vancomycin.^[84] These antibiotics are often given intravenously and used in combination.^[84] In those treated in hospital, more than 90% improve with the initial antibiotics.^[24]

Viral

Neuraminidase inhibitors may be used to treat viral pneumonia caused by influenza viruses (influenza A and influenza B).^[12] No specific antiviral medications are recommended for other types of community acquired viral pneumonias including SARS coronavirus, adenovirus, hantavirus, and parainfluenza virus.^[12] Influenza A may be treated with rimantadine or amantadine, while influenza A or B may be treated with oseltamivir, zanamivir or peramivir.^[12] These are of most benefit if they are started within 48 hours of the onset of symptoms.^[12] Many strains of H5N1 influenza A, also known as avian influenza or "bird flu", have shown resistance to rimantadine and amantadine.^[12] The use of antibiotics in viral pneumonia is recommended by some experts, as it is impossible to rule out a complicating bacterial infection.^[12] The British Thoracic Society recommends that antibiotics be withheld in those with mild disease.^[12] The use of corticosteroids is controversial.^[12]

Aspiration

In general, aspiration pneumonitis is treated conservatively with antibiotics indicated only for aspiration pneumonia.^[85] The choice of antibiotic will depend on several factors, including the suspected causative organism and whether pneumonia was acquired in the community or developed in a hospital setting. Common options include clindamycin, a combination of a beta-lactam antibiotic and metronidazole, or an aminoglycoside.^[86] Corticosteroids are sometimes used in aspiration pneumonia, but there is limited evidence to support their effectiveness.^[85]

Prognosis

With treatment, most types of bacterial pneumonia will stabilize in 3–6 days.^[87] It often takes a few weeks before most symptoms resolve.^[87] X-ray finding typically clear within four weeks and mortality is low (less than 1%).^[20][88] In the elderly or people with other lung problems, recovery may take more than 12 weeks. In persons requiring hospitalization, mortality may be as high as 10%, and in those requiring intensive care it may reach 30–50%.^[20] Pneumonia is the most common hospital-acquired infection that causes death.^[24] Before the advent of antibiotics, mortality was typically 30% in those that were hospitalized.^[16]

Complications may occur in particular in the elderly and those with underlying health problems.^[88] This may include, among others: empyema, lung abscess, bronchiolitis obliterans, acute respiratory distress syndrome, sepsis, and worsening of underlying health problems.^[88]

Clinical prediction rules

Clinical prediction rules have been developed to more objectively predict outcomes of pneumonia.^[24] These rules are often used in deciding whether or not to hospitalize the person.^[24]

• Pneumonia severity index (or PSI Score)^[24]
• CURB-65 score, which takes into account the severity of symptoms, any underlying diseases, and age^[89]

Pleural effusion, empyema, and abscess

A pleural effusion: as seen on chest X-ray. The A arrow indicates fluid layering in the right chest. The B arrow indicates the width of the right lung. The volume of the lung is reduced because of the collection of fluid around the lung.

In pneumonia, a collection of fluid may form in the space that surrounds the lung.^[90] Occasionally, microorganisms will infect this fluid, causing an empyema.^[90] To distinguish an empyema from the more common simple parapneumonic effusion, the fluid may be collected with a needle (thoracentesis), and examined.^[90] If this shows evidence of empyema, complete drainage of the fluid is necessary, often requiring a drainage catheter.^[90] In severe cases of empyema, surgery may be needed.^[90] If the infected fluid is not drained, the infection may persist, because antibiotics do not penetrate well into the pleural cavity. If the fluid is sterile, it must be drained only if it is causing symptoms or remains unresolved.^[90]

In rare circumstances, bacteria in the lung will form a pocket of infected fluid called a lung abscess.^[90] Lung abscesses can usually be seen with a chest X-ray but frequently require a chest CT scan to confirm the diagnosis.^[90] Abscesses typically occur in aspiration pneumonia, and often contain several types of bacteria. Long-term antibiotics are usually adequate to treat a lung abscess, but sometimes the abscess must be drained by a surgeon or radiologist.^[90]

Respiratory and circulatory failure

Pneumonia can cause respiratory failure by triggering acute respiratory distress syndrome (ARDS), which results from a combination of infection and inflammatory response. The lungs quickly fill with fluid and become stiff. This stiffness, combined with severe difficulties extracting oxygen due to the alveolar fluid, may require long periods of mechanical ventilation for survival.^[31]

Sepsis is a potential complication of pneumonia but occurs usually in people with poor immunity or hyposplenism. The organisms most commonly involved are Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella pneumoniae. Other causes of the symptoms should be considered such as a myocardial infarction or a pulmonary embolism.^[91]

Epidemiology

Deaths from lower respiratory infections per million persons in 2012

  24-120

  121-151

  152-200

  201-241

  242-345

  346-436

  437-673

  674-864

  865-1,209

  1,210-2,085

Disability-adjusted life year for lower respiratory infections per 100,000 inhabitants in 2004.^[92]

  no data

  less than 100

  100–700

  700–1,400

  1,400–2,100

  2,100–2,800

  2,800–3,500

  3,500–4,200

  4,200–4,900

  4,900–5,600

  5,600–6,300

  6,300–7,000

  more than 7,000

Pneumonia is a common illness affecting approximately 450 million people a year and occurring in all parts of the world.^[12] It is a major cause of death among all age groups resulting in 4 million deaths (7% of the world's total death) yearly.^[12][13] Rates are greatest in children less than five, and adults older than 75 years.^[12] It occurs about five times more frequently in the developing world than in the developed world.^[12] Viral pneumonia accounts for about 200 million cases.^[12] In the United States, as of 2009, pneumonia is the 8th leading cause of death.^[20]

Children

In 2008, pneumonia occurred in approximately 156 million children (151 million in the developing world and 5 million in the developed world).^[12] In 2010, it resulted in 1.3 million deaths, or 18% of all deaths in those under five years, of which 95% occurred in the developing world.^[12][19][93] Countries with the greatest burden of disease include India (43 million), China (21 million) and Pakistan (10 million).^[94] It is the leading cause of death among children in low income countries.^[12][13] Many of these deaths occur in the newborn period. The World Health Organization estimates that one in three newborn infant deaths is due to pneumonia.^[95] Approximately half of these deaths can be prevented, as they are caused by the bacteria for which an effective vaccine is available.^[96] In 2011, pneumonia was the most common reason for admission to the hospital after an emergency department visit in the U.S. for infants and children.^[97]

History

WPA poster, 1936/1937

Pneumonia has been a common disease throughout human history.^[98] The word is from Greek πνεύμων (pneúmōn) meaning “lung”.^[99] The symptoms were described by Hippocrates (c. 460 BC – 370 BC):^[98] "Peripneumonia, and pleuritic affections, are to be thus observed: If the fever be acute, and if there be pains on either side, or in both, and if expiration be if cough be present, and the sputa expectorated be of a blond or livid color, or likewise thin, frothy, and florid, or having any other character different from the common... When pneumonia is at its height, the case is beyond remedy if he is not purged, and it is bad if he has dyspnoea, and urine that is thin and acrid, and if sweats come out about the neck and head, for such sweats are bad, as proceeding from the suffocation, rales, and the violence of the disease which is obtaining the upper hand."^[100] However, Hippocrates referred to pneumonia as a disease "named by the ancients". He also reported the results of surgical drainage of empyemas. Maimonides (1135–1204 AD) observed: "The basic symptoms that occur in pneumonia and that are never lacking are as follows: acute fever, sticking pleuritic pain in the side, short rapid breaths, serrated pulse and cough."^[101] This clinical description is quite similar to those found in modern textbooks, and it reflected the extent of medical knowledge through the Middle Ages into the 19th century.

Edwin Klebs was the first to observe bacteria in the airways of persons having died of pneumonia in 1875.^[102] Initial work identifying the two common bacterial causes, Streptococcus pneumoniae and Klebsiella pneumoniae, was performed by Carl Friedländer^[103] and Albert Fränkel^[104] in 1882 and 1884, respectively. Friedländer's initial work introduced the Gram stain, a fundamental laboratory test still used today to identify and categorize bacteria. Christian Gram's paper describing the procedure in 1884 helped to differentiate the two bacteria, and showed that pneumonia could be caused by more than one microorganism.^[105]

Sir William Osler, known as "the father of modern medicine", appreciated the death and disability caused by pneumonia, describing it as the "captain of the men of death" in 1918, as it had overtaken tuberculosis as one of the leading causes of death in this time. This phrase was originally coined by John Bunyan in reference to "consumption" (tuberculosis).^[106][107] Osler also described pneumonia as "the old man's friend" as death was often quick and painless when there were much slower and more painful ways to die.^[16]

Several developments in the 1900s improved the outcome for those with pneumonia. With the advent of penicillin and other antibiotics, modern surgical techniques, and intensive care in the 20th century, mortality from pneumonia, which had approached 30%, dropped precipitously in the developed world. Vaccination of infants against Haemophilus influenzae type B began in 1988 and led to a dramatic decline in cases shortly thereafter.^[108] Vaccination against Streptococcus pneumoniae in adults began in 1977, and in children in 2000, resulting in a similar decline.^[109]

Society and culture

Awareness

Due to the relatively low awareness of the disease, 12 November was declared as the annual World Pneumonia Day, a day for concerned citizens and policy makers to take action against the disease, in 2009.^[110][111]

Costs

The global economic cost of community-acquired pneumonia has been estimated at $17 billion annually.^[20] Other estimates are considerably higher. In 2012 the estimated aggregate costs of treating pneumonia in the United States were $20 billion;^[112] the median cost of a single pneumonia-related hospitalization is over $15,000.^[113] According to data released by the Centers for Medicare and Medicaid Services, average 2012 hospital charges for inpatient treatment of uncomplicated pneumonia in the U.S. were $24,549 and ranged as high as $124,000. The average cost of an emergency room consult for pneumonia was $943 and the average cost for medication was $66.^[114] Aggregate annual costs of treating pneumonia in Europe have been estimated at €10 billion.^[115]

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Bibliography

• John F. Murray (2010). Murray and Nadel's textbook of respiratory medicine (5th ed.). Philadelphia, PA: Saunders/Elsevier. ISBN 1416047107.
• Burke A. Cunha, ed. (2010). Pneumonia essentials (3rd ed.). Sudbury, MA: Physicians' Press. ISBN 0763772208.

External links

• Pneumonia at DMOZ

Classification	ICD-10: J12, J13, J14, J15, J16, J17, J18, P23 ICD-9-CM: 480-486, 770.0 MeSH: D011014 DiseasesDB: 10166
External resources	MedlinePlus: 000145 eMedicine: search/pneumonia Patient UK: Pneumonia