Desosaminyl transferase EryCIII
| Desosaminyl transferase EryCIII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.278 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Desosaminyl transferase EryCIII (EC 2.4.1.278, EryCIII) is an enzyme with systematic name dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose:3-alpha-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B dTDP + erythromycin D
The enzyme is involved in erythromycin biosynthesis.
References
- ↑ Yuan, Y.; Chung, H.S.; Leimkuhler, C.; Walsh, C.T.; Kahne, D.; Walker, S. (2005). "In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides". J. Am. Chem. Soc. 127 (41): 14128–14129. doi:10.1021/ja053704n. PMC 2525786
. PMID 16218575. - ↑ Lee, H.Y.; Chung, H.S.; Hang, C.; Khosla, C.; Walsh, C.T.; Kahne, D.; Walker, S. (2004). "Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway". J. Am. Chem. Soc. 126 (32): 9924–9925. doi:10.1021/ja048836f. PMID 15303858.
- ↑ Moncrieffe, M.C.; Fernandez, M.J.; Spiteller, D.; Matsumura, H.; Gay, N.J.; Luisi, B.F.; Leadlay, P.F. (2012). "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII". J. Mol. Biol. 415 (1): 92–101. doi:10.1016/j.jmb.2011.10.036. PMC 3391682. PMID 22056329.
External links
- Desosaminyl transferase EryCIII at the US National Library of Medicine Medical Subject Headings (MeSH)
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