A-1,6-mannosyl-glycoprotein 2-b-N-acetylglucosaminyltransferase
| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.143 | ||||||||
| CAS number | 105913-04-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143, N-acetylglucosaminyltransferase II, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II, acetylglucosaminyltransferase II, uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase, UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, GnTII) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R UDP + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
References
- ↑ Bendiak, B.; Schacter, H. (1987). "Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine:α-D-mannoside β1-2 N-acetylglucosaminyltransferase II from rat liver". J. Biol. Chem. 262 (12): 5775–5783. PMID 2952644.
- ↑ Harpaz, N.; Schachter, H. (1980). "Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:α-D-mannoside β2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:α-D-mannoside β2-N-acetylglucosaminyltransferase II, partial purification, and substrate specificity". J. Biol. Chem. 255 (10): 4885–4893. PMID 6445358.
- ↑ Mendicino, J.; Chandrasekaran, E.V.; Anumula, K.R.; Davila, M. (1981). "Isolation and properties of α-D-mannose:β-1,2-N-acetylglucosaminyltransferase from trachea mucosa". Biochemistry. 20 (4): 967–976. doi:10.1021/bi00507a050. PMID 6452163.
- ↑ Oppenheimer, C.L.; Eckhardt, A.E.; Hill, R.L. (1981). "The nonidentity of porcine N-acetylglucosaminyltransferases I and II". J. Biol. Chem. 256 (22): 11477–11482. PMID 6457827.
- ↑ Schachter, H.; Narasimhan, S.; Gleeson, P.; Vella, G. (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods Enzymol. 98: 98–134. doi:10.1016/0076-6879(83)98143-0. PMID 6366476.
- ↑ Bendiak, B.; Schachter, H. (1987). "Control of glycoprotein synthesis. Kinetic mechanism, substrate specificity, and inhibition characteristics of UDP-N-acetylglucosamine:α-D-mannoside β-1-2 N-acetylglucosaminyltransferase II from rat liver". J. Biol. Chem. 262 (12): 5784–5790. PMID 2952644.
External links
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)