B-1,4-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Identifiers
EC number	2.4.1.144
CAS number	83744-93-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144, N-acetylglucosaminyltransferase III, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III, beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTIII) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R $\rightleftharpoons$ UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References

1. Narasimhan, S. (1982). "Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide β4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in β1-4 linkage to the β-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides". J. Biol. Chem. 257 (17): 10235–10242. PMID 6213618.
2. Schachter, H.; Narasimhan, S.; Gleeson, P.; Vella, G. (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods Enzymol. 98: 98–134. doi:10.1016/0076-6879(83)98143-0. PMID 6366476.

External links

• Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)