Glucosylceramide beta-1,4-galactosyltransferase
| Glucosylceramide beta-1,4-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.274 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Involved in the synthesis of several different major classes of glycosphingolipids.
References
- ↑ Chatterjee, S.; Castiglione, E. (1987). "UDPgalactose:glucosylceramide β1→4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochim. Biophys. Acta. 923 (1): 136–142. doi:10.1016/0304-4165(87)90136-X. PMID 3099851.
- ↑ Trinchera, M.; Fiorilli, A.; Ghidoni, R. (1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→4galactosyltransferase". Biochemistry. 30 (10): 2719–2724. doi:10.1021/bi00224a021. PMID 1900430.
- ↑ Chatterjee, S.; Ghosh, N.; Khurana, S. (1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, β 1-4 galactosyltransferase from human kidney". J. Biol. Chem. 267 (10): 7148–7153. PMID 1551920.
- ↑ Nomura, T.; Takizawa, M.; Aoki, J.; Arai, H.; Inoue, K.; Wakisaka, E.; Yoshizuka, N.; Imokawa, G.; Dohmae, N.; Takio, K.; Hattori, M.; Matsuo, N. (1998). "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide β-1,4-galactosyltransferase from rat brain". J. Biol. Chem. 273 (22): 13570–13577. doi:10.1074/jbc.273.22.13570. PMID 9593693.
- ↑ Takizawa, M.; Nomura, T.; Wakisaka, E.; Yoshizuka, N.; Aoki, J.; Arai, H.; Inoue, K.; Hattori, M.; Matsuo, N. (1999). "cDNA cloning and expression of human lactosylceramide synthase". Biochim. Biophys. Acta. 1438 (2): 301–304. doi:10.1016/S1388-1981(99)00051-7. PMID 10320813.
External links
- Glucosylceramide beta-1,4-galactosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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