Isotuberculosinol synthase

Isotuberculosinol synthase
Identifiers
EC number 3.1.7.9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Isotuberculosinol synthase (EC 3.1.7.9, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming).[1][2] This enzyme catalyses the following chemical reaction

tuberculosinyl diphosphate + H2O (13S)-isotuberculosinol + diphosphate

This enzyme is present in species of Mycobacterium that cause tuberculosis.

References

  1. Nakano, C.; Ootsuka, T.; Takayama, K.; Mitsui, T.; Sato, T.; Hoshino, T. (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Biosci. Biotechnol. Biochem. 75 (1): 75–81. doi:10.1271/bbb.100570. PMID 21228491.
  2. Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T. (2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Org. Biomol. Chem. 9 (7): 2156–2165. doi:10.1039/c0ob00884b. PMID 21290071.
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