Lactotriaosylceramide beta-1,4-galactosyltransferase

Lactotriaosylceramide beta-1,4-galactosyltransferase
Identifiers
EC number 2.4.1.275
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lactotriaosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.275, beta4Gal-T4, UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1] This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

References

  1. Schwientek, T.; Almeida, R.; Levery, S.B.; Holmes, E.H.; Bennett, E.; Clausen, H. (1998). "Cloning of a novel member of the UDP-galactose:β-N-acetylglucosamine β1,4-galactosyltransferase family, β4Gal-T4, involved in glycosphingolipid biosynthesis". J. Biol. Chem. 273 (45): 29331–29340. doi:10.1074/jbc.273.45.29331. PMID 9792633.
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