Lenvatinib

Lenvatinib
Clinical data
Trade names Lenvima
AHFS/Drugs.com lenvima
Routes of
administration		 Oral
ATC code L01XE29 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 85% (estimated)
Protein binding 98–99%
Metabolism CYP3A4, aldehyde oxidase, non-enzymatic
Metabolites Desmethyl-lenvatinib (M2) and others
Biological half-life 28 hours
Excretion ~65% feces, 25% urine
Identifiers
Synonyms E7080
CAS Number 417716-92-8 N
PubChem (CID) 9823820
IUPHAR/BPS 7426
DrugBank DB09078 N
ChemSpider 7999567 YesY
UNII EE083865G2 YesY
KEGG D09919 N
ChEBI CHEBI:85994 N
ChEMBL CHEMBL1289601 N
Chemical and physical data
Formula C21H19ClN4O4
Molar mass 426.853 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Lenvatinib (trade name Lenvima) is an anti-cancer drug for the treatment of certain kinds of thyroid cancer, and potentially for other cancers as well. It was developed by Eisai Co. and acts as a multiple kinase inhibitor against the VEGFR1, VEGFR2 and VEGFR3 kinases.[1]

Medical uses

Lenvatinib is used for the treatment of differentiated thyroid cancer that is either locally recurrent or metastatic, progressive, and did not respond to treatment with radioactive iodine (radioiodine).[2][3]

Adverse effects

Hypertension (high blood pressure) was the most common side effect in studies (73% of patients, versus 16% in the placebo group), followed by diarrhoea (67% vs. 17%) and fatigue (67% vs. 35%).[3] Other common side effects included decreased appetite, hypotension (low blood pressure), thrombocytopenia (low blood platelet count), nausea, muscle and bone pain.[2]

Interactions

As lenvatinib moderately prolongs QT time, addition of other drugs with this property could increase the risk of a type of abnormal heart rhythm, namely torsades de pointes. No relevant interactions with enzyme inhibitors and inducers are expected.[3]

Pharmacology

Mechanism of action

Lenvatinib inhibits the three main vascular endothelial growth factor receptors VEGFR1, 2 and 3, as well as fibroblast growth factor receptors (FGFR) 1, 2, 3 and 4, platelet-derived growth factor receptor (PDGFR) alpha, c-Kit, and the RET proto-oncogene. Some of these proteins play roles in cancerogenic signalling pathways. VEGFR2 inhibition is thought to be the main reason for the most common side effect, hypertension.[2]

Pharmacokinetics

Lenvatinib is absorbed quickly from the gut, reaching peak blood plasma concentrations after one to four hours (three to seven hours if taken with food). Bioavailability is estimated to be about 85%. The substance is almost completely (98–99%) bound to plasma proteins, mainly albumin.[2]

Lenvatinib is metabolized by the liver enzyme CYP3A4 to desmethyl-lenvatinib (M2). M2 and lenvatinib itself are oxidized by aldehyde oxidase (AO) to substances called M2' and M3',[4] the main metabolites in the feces. Another metabolite, also mediated by a CYP enzyme, is the N-oxide M3. Non-enzymatic metabolization also occurs, resulting in a low potential for interactions with enzyme inhibitors and inducers.[2]

Lenvatinib is oxidized by cytochrome P450 enzymes (CYP), and further metabolized to the quinolinones M2' and M3' by aldehyde oxidase (AO).[4]

Terminal half-life is 28 hours, with about two thirds being excreted via the feces, and one quarter via the urine.[2]

Chemistry

Lenvatinib is used in form of the mesylate salt (CAS number 857890-39-2 ).

History

A phase I clinical trial in cancer patients was performed in 2006.[5] A phase III trial treating thyroid cancer patients started in March 2011.[6]

Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not respond to radioiodine in the US and Japan in 2012 and in Europe in 2013.[7]

In February 2015, the U.S. FDA approved lenvatinib for treatment of progressive, radioiodine refractory differentiated thyroid cancer.[8] In May 2015, European Medicines Agency (EMA) approved the drug for the same indication.[9]

In May 2016, the FDA approved it (in combination with everolimus) for the treatment of advanced renal cell carcinoma following one prior anti-angiogenic therapy.[10]

References

  1. ↑ Matsui, J.; Funahashi, Y.; Uenaka, T.; Watanabe, T.; Tsuruoka, A.; Asada, M. (2008). "Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase". Clinical Cancer Research. 14 (17): 5459–65. doi:10.1158/1078-0432.CCR-07-5270. PMID 18765537.
  2. 1 2 3 4 5 6 Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.
  3. 1 2 3 FDA Professional Drug Information for Lenvima.
  4. 1 2 Inoue, K (2014). "Oxidative Metabolic Pathway of Lenvatinib Mediated by Aldehyde Oxidase". Drug Metab Dispos. doi:10.1124/dmd.114.058073. PMID 24914245.
  5. ↑ Glen, H; D. Boss; T. R. Evans; M. Roelvink; et al. (2007). "A phase I dose finding study of E7080 in patients (pts) with advanced malignancies". Journal of Clinical Oncology, ASCO Annual Meeting Proceedings Part I. 25 (18S): 14073.
  6. ↑ Clinical trial number NCT01321554 for "A Trial of E7080 in 131I-Refractory Differentiated Thyroid Cancer" at ClinicalTrials.gov
  7. ↑ "Phase III trial shows lenvatinib meets primary endpoint of progression free survival benefit in treatment of radioiodine-refractory differentiated thyroid cancer" (PDF). Eisai. 3 February 2014.
  8. ↑ U.S. Food and Drug Administration. Hematology/Oncology (Cancer) Approvals & Safety Notifications.
  9. ↑ European Medicines Agency Summary of the European public assessment report (EPAR) for Lenvima
  10. ↑ http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm501070.htm
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