Neuregulin 4

NRG4
Identifiers
Aliases	NRG4, HRG4, neuregulin 4
External IDs	MGI: 1933833 HomoloGene: 12921 GeneCards: NRG4
Gene ontology Molecular function • protein binding • growth factor activity • receptor binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • membrane • plasma membrane • extracellular fluid • extracellular region • intracellular Biological process • animal organ development • intracellular signal transduction • MAPK cascade • phosphatidylinositol-mediated signaling • positive regulation of GTPase activity • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • regulation of cell motility Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	145957	83961
Ensembl	ENSG00000169752	ENSMUSG00000032311
UniProt	Q8WWG1	Q9WTX4
RefSeq (mRNA)	NM_138573	NM_032002
RefSeq (protein)	NP_612640.1	NP_114391.1
Location (UCSC)	Chr 15: 75.94 – 76.06 Mb	Chr 9: 55.22 – 55.33 Mb
PubMed search	[1]	[2]
Wikidata

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Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.^[3][4][5]

Function

The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.^[5]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: NRG4 neuregulin 4".
4. Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
5. Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (April 1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681–9. doi:10.1038/sj.onc.1202631. PMID 10348342.
6. Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E (December 2004). "Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients". Br. J. Cancer. 91 (12): 2034–41. doi:10.1038/sj.bjc.6602251. PMC 2409781. PMID 15583696.

Further reading

• Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP (January 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hayes NV, Newsam RJ, Baines AJ, Gullick WJ (2008). "Characterization of the cell membrane-associated products of the Neuregulin 4 gene.". Oncogene. 27 (5): 715–20. doi:10.1038/sj.onc.1210689. PMID 17684490.
• Hayes NV, Blackburn E, Smart LV, et al. (2007). "Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer.". Clin. Cancer Res. 13 (11): 3147–55. doi:10.1158/1078-0432.CCR-06-2237. PMID 17545517.