Mouthwash

For other uses, see Mouthwash (disambiguation).

Mouthwash, mouth rinse, oral rinse or mouth bath,[1] is a liquid which is held in the mouth passively or swilled around the mouth by contraction of the perioral muscles and/or movement of the head, and may be gargled, where the head is tilted back and the liquid bubbled at the back of the mouth.

Usually mouthwashes are an antiseptic solution intended to reduce the microbial load in the oral cavity, although other mouthwashes might be given for other reasons such as for their analgesic, anti-inflammatory or anti-fungal action. Additionally, some rinses act as saliva substitutes to neutralize acid and keep the mouth moist in xerostomia (dry mouth).[2][3] Cosmetic mouthrinses temporarily control or reduce bad breath and leave the mouth with a pleasant taste.[4]

Use

Common use involves rinsing the mouth with about 20 ml (2/3 fl oz) of mouthwash. The wash is typically swished or gargled for about half a minute and then spat out. Most companies suggest not drinking water immediately after using mouthwash. In some brands, the expectorate is stained, so that one can see the bacteria and debris.[5][6] Mouthwash should not be used immediately after brushing the teeth so as not to wash away the beneficial fluoride residue left from the toothpaste. Similarly, the mouth should not be rinsed out with water after brushing. Patients were told to "spit don't rinse" after toothbrushing as part of an National Health Service campaign in the UK.[7]

Gargling is where the head is tilted back, allowing the mouthwash to sit in the back of the mouth while exhaling, causing the liquid to bubble. Gargling is practiced in Japan for perceived prevention of viral infection. One commonly used way is with infusions or tea. In some cultures, gargling is usually done in private, typically in a bathroom at a sink so the liquid can be rinsed away.[8]

Benefits

The most common use of mouthwash is commercial antiseptics, which are used at home as part of an oral hygiene routine. Some manufacturers of mouthwash state that antiseptic and anti-plaque mouth rinse kill the bacterial plaque that causes cavities, gingivitis, and bad breath. Anti-cavity mouth rinse uses fluoride to protect against tooth decay. It is, however, generally agreed that the use of mouthwash does not eliminate the need for both brushing and flossing.[9][10][11] The American Dental Association asserts that regular brushing and proper flossing are enough in most cases, although they approve many mouthwashes that do not contain ethanol (in addition to regular dental check-ups).[12] For many patients, however, the mechanical methods could be tedious and time-consuming and additionally some local conditions may render them especially difficult. Chemotherapeutic agents, including mouthrinses, could have a key role as adjuncts to daily home care, preventing and controlling supragingival plaque, gingivitis and oral malodor.[13] Another common use of mouthwash is prior to and after oral surgery procedures such as tooth extraction.

Side effects

Minor and transient side effects of commercial mouthwashes are very common, such as taste disturbance, tooth staining, sensation of a dry mouth, etc. Alcohol-containing mouthwashes may make dry mouth and halitosis worse since it dries out the mouth.[14][15] Soreness, ulceration and redness may sometimes occur (e.g. aphthous stomatitis, allergic contact stomatitis) if the person is allergic or sensitive to mouthwash ingredients such as preservatives, coloring, flavors and fragrances. Such effects might be reduced or eliminated by diluting the mouthwash with water, using a different mouthwash (e.g. salt water), or foregoing mouthwash entirely.

Typical formulation of commercial mouthwashes by active ingredient

Each commercial brand of mouthwash has different ingredients. The active ingredients are usually

Antiseptic

Antimalodor

Antiplaque/oxidizing

Anticavity

Antiinflammatory

Analgesics

Saliva substitute

Topical agents

to prevent bleeding etc., mouthwashes with ingredients such as tranexamic acid are locally applied

Phenolic compounds

phenolic compounds include essential oil constituents that have some antibacterial properties,[16][25] like phenol,[16] thymol,[16] eugenol,[16] eucalyptol[26] or menthol.

Inactive ingredients

Astringents

Astringents like zinc chloride to provide a pleasant-tasting sensation and shrink tissues[27] or Alternative mouthwash ingredients might include persica or alum.

Carriers

Alcohol is added to mouthwash not to destroy bacteria but to act as a carrier agent for essential active ingredients such as menthol, eucalyptol and thymol which help to penetrate plaque.[16]

Preservatives

Commercial mouthwashes usually contain a preservative such as sodium benzoate or methylparaben to preserve freshness once the container has been opened. Many newer brands are alcohol-free and contain odor-elimination agents such as oxidizers, as well as odor-preventing agents such as zinc ion to keep future bad breath from developing.

Flavoring agents

flavoring agents include sweeteners such as sorbitol, sucralose, sodium saccharin, and xylitol (which doubles as a bacterial inhibitor).[28]

Others

Custom formulations

Custom formulations of mouthwash are non-standardized mixtures of ingredients prescribed for a specific purpose, such as for use prior to oral surgery or to treat the pain associated with mucositis caused by radiation therapy or chemotherapy. It is also prescribed for aphthous ulcers, other oral ulcers, and other mouth pain.[30] Variations are common, and some are done with over-the-counter products. Magic mouthwashes are intended to combine ingredients to treat a variety of oral conditions. Magic mouthwashes are typically compounded in a pharmacy from a doctor's prescription.[31][32]

Common ingredients include: diphenhydramine (antihistamine), glucocorticoids (anti-inflammatory), lidocaine/xylocaine (local anesthetic),[33] Maalox (antacid), nystatin (antifungal for oral candidiasis), sucralfate (coating agent), tetracycline or erythromycin (antibiotics).[30]

Despite a lack of evidence that magic mouthwashes are effective in decreasing the pain of oral lesions, many patients and prescribers continue to use them. There has been only one controlled study to evaluate the efficacy of magic mouthwash; it shows no difference in efficacy among the most common formulation and other agents such as chlorhexidine and a saline/baking soda solution. Current guidelines suggest that saline solution is just as effective as magic mouthwash in pain relief or shortening of healing time of oral mucositis from cancer therapies.[30]

Because magic mouthwash has no standard formulation, its use involves concerns about patient safety. It is important that the prescriber and pharmacist are in specific agreement about exactly what is being prescribed, so as to minimize the potential for drug interaction and the possibility of drug allergy.

Specific mouthwash ingredients - Common formulations

Alcohol

An example of a commercial mouthwash brand which is alcohol-free

Sometimes a significant amount of alcohol (up to 27% vol) is added,[34] as a carrier for the flavor, to provide "bite".[35] Because of the alcohol content, it is possible to fail a breathalyzer test after rinsing although breath alcohol levels return to normal after 10 minutes.[36] In addition, alcohol is a drying agent, which encourages bacterial activity in the mouth, releasing more malodorous volatile sulfur compounds. Therefore, alcohol-containing mouthwash may temporarily worsen halitosis in those who already have it, or indeed be the sole cause of halitosis in other individuals.[29]

It is hypothesized that alcohol mouthwashes acts as a carcinogen (cancer-inducing). Generally, there is no scientific consensus about this.[37][38][39] One review stated:

There is now sufficient evidence to accept the proposition that developing oral cancer is increased or contributed to by the use of alcohol-containing mouthwashes. Whilst many of these products may have been shown to be effective in penetrating oral microbial biofilms in vitro and reducing oral bacterial load, it would be wise to restrict their use to short-term therapeutic situations if needed. Perhaps the use of mouthwashes that do not contain alcohol may be equally effective. Further, mouthrinses should be prescribed by dentists, like any other medication. There may well be a reason for the use of alcohol-containing mouthrinses, but only for a particular situation and for a limited and controlled period of time. As such, patients should be provided with written instructions for mouthwash use, and mouthwash use should be restricted to adults for short durations and specific, clearly defined reasons. It is the opinion of the authors that, in light of the evidence currently available of the association of alcohol-containing mouthwashes with the development of oral cancer, it would be inadvisable for oral healthcare professionals to recommend the long-term use of alcohol-containing mouthwashes.[40]

The same researchers also state that the risk of acquiring oral cancer rises almost five times for users of alcohol-containing mouthwash who neither smoke nor drink (with a higher rate of increase for those who do).[41] In addition, the authors highlight side effects from several mainstream mouthwashes that included dental erosion and accidental poisoning[42] of children. The review garnered media attention[43] and conflicting opinions from other researchers. Yinka Ebo of Cancer Research UK disputed the findings, concluding that "there is still not enough evidence to suggest that using mouthwash that contains alcohol will increase the risk of mouth cancer".[44] Studies conducted in 1985,[45] 1995,[46] 2003,[47] and 2012[48] did not support an association between alcohol-containing mouth rinses and oral cancer. Andrew Penman, chief executive of The Cancer Council New South Wales, called for further research on the matter.[49] In a March 2009 brief, the American Dental Association said "the available evidence does not support a connection between oral cancer and alcohol-containing mouthrinse".[50] Many newer brands of mouthwash are alcohol free, not just in response to consumer concerns about oral cancer, but also to cater for religious groups who abstain from alcohol consumption.

Chlorhexidine digluconate

Chlorhexidine digluconate is a chemical antiseptic and is used in a 0.12-0.2% solution as a mouthwash. It has significant anti-plaque action, but also some anti-fungal action.[51] It is especially effective against Gram-negative rods.[51] It is sometimes used as an adjunct to prevent dental caries and to treat periodontal disease,[51] although it does not penetrate into periodontal pockets well.[52] Chlorhexidine mouthwash alone is unable to prevent plaque, so it is not a substitute for regular toothbrushing and flossing.[52] In the short term, if toothbrushing is impossible due to pain, as may occur in primary herpetic gingivostomatitis, chlorhexidine is used as temporary substitute for other oral hygiene measures.[52] It is not suited for use in acute necrotizing ulcerative gingivitis however.[52] Rinsing with chlorhexidine mouthwash before a tooth extraction reduces the risk of dry socket, a painful condition where the blood clot is lost from an extraction socket and bone is exposed to the oral cavity.[53] Other uses of chlorhexidine mouthwash include prevention of oral candidiasis in immunocompromised persons,[52] treatment of denture-related stomatitis, and many other uses.[52]

Chlorhexidine has good substantivity (the ability of a mouthwash to bind to hard and soft tissues in the mouth).[51] However, chlorhexidine binds to tannins, meaning that prolonged use in persons who consume coffee, tea or red wine is associated with extrinsic staining (i.e. removable staining) of teeth.[51] Chlorhexidine is rarely associated with other issues like overgrowth of enterobacteria in persons with leukemia, desquamation and irritation of oral mucosa, salivary gland pain and swelling, and hypersensitivity reactions including anaphylaxis.[51]

Essential oils and phenols

Essential oils are oils which have been extracted from plants. Mouthwashes based on essential oils could be more effective than traditional mouthcare - for anti-gingival treatments. [25] [54] They have been found effective in reducing halitosis, and are being used in several commercial mouthwashes.

Phenolic mouthwashes (e.g. Methylsalicylate in Listerine) have some anti-plaque action but less substantivity than chlorhexidine.[51] They do not stain teeth.[51]

Fluoride

Most people using fluoridated toothpastes do not require fluoride-containing mouth rinses, rather fluoride mouthwashes are sometimes used in individuals who are at high risk of dental decay, due to dental caries or people with xerostomia.[55][56]

Xylitol

Xylitol stimulates salivary function due to its sweetness and taste and helps restore the mouth to a neutral level of acidity.[2] Xylitol rinses aid in cavity prevention and have been used as substitute for Alcohol to avoid dryness of mouth associated with Alcohol.[2]

Sodium lauryl sulfate

Sodium lauryl sulfate (SLS) is user as a foaming agent in many oral hygiene products including many mouthwashes. Some may suggest that it is probably advisable to use mouthwash at least an hour after brushing with toothpaste when the toothpaste contains SLS, since the anionic compounds in the SLS toothpaste can deactivate cationic agents present in the mouthrinse.[57] However, many of the popular mouthwashes also contain SLS as an ingredient (e.g., Listerine Total Care).

Triclosan

Triclosan is a non-ionic chlorinate bisphenol antiseptic. When used in mouthwash (e.g. 0.03%), there is moderate substantivity, broad spectrum anti-bacterial action, some anti-fungal action and significant anti-plaque effect, especially when combined with copolymer or zinc citrate.[51] Triclosan does not cause staining of the teeth.[51] The safety of triclosan has been questioned.[58]

Specific mouthwash ingredients - Custom formulations

Benzydamine (Difflam)

In painful oral conditions such as aphthous stomatitis, analgesic mouthrinses (e.g. benzydamine mouthwash, or "Difflam") are sometimes used to ease pain, commonly used before meals to reduce discomfort while eating.

Betamethasone

Betamethasone is sometimes used as an anti-inflammatory, corticosteroid mouthwash. It may be used for severe inflammatory conditions of the oral mucosa such as the severe forms of aphthous stomatitis.[59]:209

Cetylpyridinium chloride

Cetylpyridinium chloride containing mouthwash (e.g. 0.05%) is used in some specialized mouthwashes for halitosis.[60] Cetylpyridinium chloride mouthwash has less anti-plaque effect than chlorhexidine and may cause staining of teeth, or sometimes an oral burning sensation or ulceration.[51]

Edible oils

In traditional Ayurvedic medicine, the use of oil mouthwashes is called "Kavala" ("oil swishing") or "Gandusha",[61][62] and this practice has more recently been re-marketed by the complimentary and alternative medicine industry as "oil pulling".[63] Its promoters claim it works by "pulling out" "toxins", which are known as ama in Ayurvedic medicine, and thereby reducing inflammation.[64] Ayurvedic literature suggests oil pulling is capable of improving oral and systemic health, including a benefit in conditions such as headaches, migraines, diabetes mellitus, asthma,[61] and acne, as well as whitening teeth.[65]

Oil pulling has received little study and there is little evidence to support claims made by the technique's advocates.[62] When compared with chlorhexidine in one small study, it was found to be less effective at reducing oral bacterial load,[66][67] otherwise the health claims of oil pulling have failed scientific verification[62] or have not been investigated.[62] There is a report of lipid pneumonia caused by accidental inhalation of the oil during oil pulling.[68][69][70]

The mouth is rinsed with approximately one tablespoon of oil for 10–20 minutes then spat out.[62][65] Sesame oil, coconut oil and ghee are traditionally used,[65] but newer oils such as sunflower oil are also used.[65]

Hydrogen peroxide

Hydrogen peroxide can be used as an oxidizing mouthwash (e.g. Peroxyl, 1.5%).[52] It kills anearobic bacteria, and also has a mechanical cleansing action when it froths as it comes into contact with debris in mouth.[52] It is often used in the short term to treat acute necrotising ulcerative gingivitis.[52] Side effects with prolonged use might occur, including hypertrophy of the lingual papillae.[52]

Lactoperoxidase

Lactoperoxidase has been used in mouthrinses (e.g. Biotene) to reduce oral bacteria and hence the acid produced by bacteria.[24]

Providone/iodine

A 2005 study found that gargling three times a day with simple water or with a Povidone-iodine solution (although with less effectiveness) was effective in preventing upper respiratory infection and decreasing the severity of symptoms if contracted.[71] A later study found that the same procedure did not prevent influenza-like illnesses.[72] Other sources attribute the benefit to a simple placebo effect.[73]

Sanguinarine

Sanguinarine-containing mouthwashes are marketed as anti-plaque and anti-malodor.[51] It is a toxic alkaloid herbal extract, obtained from plants such as Sanguinaria canadensis (Bloodroot), Argemone mexicana (Mexican Prickly Poppy) and others.[51] However, its use is strongly associated with development of leukoplakia (a white patch in the mouth), usually in the buccal sulcus.[51][74] This type of leukoplakia has been termed "sanguinaria-associated keratosis" and more than 80% of people with leukoplakia in the vestibule of the mouth have used this substance. Upon stopping contact with the causative substance, the lesions may persist for years. Although this type of leukoplakia may show dysplasia, the potential for malignant transformation is unknown.[75] Ironically, elements within the complimentary and alternative medicine industry promote the use of sanguinaria as a therapy for cancer.

Sodium bicarbonate (baking soda)

Sodium bicarbonate is sometimes combined with salt to make a simple homemade mouthwash, indicated for any of the reasons that a salt water mouthwash might be used. Pre-mixed mouthwashes of 1% sodium bicarbonate and 1.5% sodium chloride in aqueous solution are marketed,[52] although pharmacists will easily be able to produce such a formulation from the base ingredients when required. Sodium bicarbonate mouthwash is sometimes used to remove viscous saliva and to aid visualization of the oral tissues during examination of the mouth.[59]:4

Sodium chloride (salt)

Hot salt water mouth baths (or hot salt water mouth washes, sometimes abbreviated to "HSWMW") are also routinely used after oral surgery, to keep food debris out of healing wounds and to prevent infection. Some oral surgeons consider salt water mouthwashes the mainstay of wound cleanliness after surgery.[76] In dental extractions, hot salt water mouthbaths should start about 24 hours after a dental extraction.[76] The term mouth bath implies that the liquid is passively held in the mouth rather than vigorously swilled around, which could dislodge a blood clot. Once the blood clot has stabilized, the mouth wash can be used more vigorously.[76] These mouthwashes tend to be advised about 6 times per day, especially after meals to remove food from the socket.[76]

Salt water mouth wash is made by dissolving 0.5–1 teaspoon of table salt into a cup of water,[1][52][76] which is as hot as possible without causing discomfort in the mouth. Saline has a mechanical cleansing action and an antiseptic action as it is a hypertonic solution in relation to bacteria, which undergo lysis. The heat of the solution produces a therapeutic increase in blood flow (hyperemia)[52] to the surgical site, promoting healing.[1] Hot salt water mouthwashes also encourage the draining of pus from dental abscesses.[77] Conversely, if heat is applied on the side of the face (e.g., hot water bottle) rather than inside the mouth, it may cause a dental abscess to drain extra-orally, which is later associated with an area of fibrosis on the face (see cutaneous sinus of dental origin).[76] Gargling with salt water is said to reduce the symptoms of a sore throat.[78]

Tetracycline

Tetracycline is an antibiotic which may sometimes be used as a mouthwash in adults (it causes red staining of teeth in children). It is sometimes use for herpetiforme ulceration (an uncommon type of aphthous stomatitis), but prolonged use may lead to oral candidiasis as the fungal population of the mouth overgrows in the absence of enough competing bacteria.[59]:209

Tranexamic acid

4.8% tranexamic acid solution is sometimes used as an antifibrinolytic mouthwash to prevent bleeding during and after oral surgery in persons with coagulopathies (clotting disorders) or who are taking anticoagulants (blood thinners such as warfarin).[79]:473

Example brands of common commercial mouthwashes

History

Listerine advertisement, 1932.
Swedish ad for toiletries, 1905/1906.

The first known references to mouth rinsing is in Ayurveda and Chinese medicine,[80] about 2700 BC, for treatment of gingivitis. Later, in the Greek and Roman periods, mouth rinsing following mechanical cleansing became common among the upper classes, and Hippocrates recommended a mixture of salt, alum, and vinegar.[81] The Jewish Talmud, dating back about 1,800 years, suggests a cure for gum ailments containing "dough water" and olive oil.[82]

Before Europeans came to the Americas, Native North American and Mesoamerican cultures used mouthwashes, often made from plants such as Coptis trifolia.[83] Indeed, Aztec dentistry was more advanced than European dentistry of the age.[83] Peoples of the Americas used salt water mouthwashes for sore throats, and other mouthwashes for problems such as teething and mouth ulcers.[83]

Anton van Leeuwenhoek, the famous 17th century microscopist, discovered living organisms (living, because they were mobile) in deposits on the teeth (what we now call dental plaque). He also found organisms in water from the canal next to his home in Delft. He experimented with samples by adding vinegar or brandy and found that this resulted in the immediate immobilization or killing of the organisms suspended in water. Next he tried rinsing the mouth of himself and somebody else with a mouthwash containing vinegar or brandy and found that living organisms remained in the dental plaque. He concluded—correctly—that the mouthwash either did not reach, or was not present long enough, to kill the plaque organisms.[84] In 1892, German Richard Seifert invented mouthwash product Odol, which was produced by company founder Karl August Lingner (1861-1916) in Dresden.[85]

That remained the state of affairs until the late 1960s when Harald Loe (at the time a professor at the Royal Dental College in Aarhus, Denmark) demonstrated that a chlorhexidine compound could prevent the build-up of dental plaque. The reason for chlorhexidine effectiveness is that it strongly adheres to surfaces in the mouth and thus remains present in effective concentrations for many hours.[86]

Since then commercial interest in mouthwashes has been intense and several newer products claim effectiveness in reducing the build-up in dental plaque and the associated severity of gingivitis, in addition to fighting bad breath. Many of these solutions aim to control the Volatile Sulfur Compound (VSC)-creating anaerobic bacteria that live in the mouth and excrete substances that lead to bad breath and unpleasant mouth taste.[87][88] For example, the number of mouthwash variants in the United States of America has grown from 15 (1970) to 66 (1998) to 113 (2012).[89]

Research

Research in the field of microbiotas shows that only a limited set of microbes cause tooth decay, with most of the bacteria in the human mouth being harmless. Focused attention on cavity-causing bacteria such as Streptococcus mutans has led research into new mouthwash treatments that prevent these bacteria from initially growing. While current mouthwash treatments must be used with a degree of frequency to prevent this bacteria from regrowing, future treatments could provide a viable long term solution.[90]

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