Nucleoporin 35

NUP35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LIR
Identifiers
Aliases	NUP35, MP-44, MP44, NP44, NUP53, nucleoporin 35kDa, nucleoporin 35
External IDs	MGI: 1916732 HomoloGene: 44517 GeneCards: NUP35
Gene ontology Molecular function • nucleotide binding • single-stranded DNA binding • protein binding • phospholipid binding • nucleocytoplasmic transporter activity Cellular component • nuclear lamina • nuclear membrane • nuclear envelope • intracellular membrane-bounded organelle • membrane • plasma membrane • nuclear pore • nucleoplasm • nuclear pore central transport channel • nuclear pore nuclear basket • intermediate filament cytoskeleton • nucleus Biological process • mRNA transport • regulation of transcription, DNA-templated • viral transcription • protein sumoylation • mitotic nuclear envelope disassembly • transport • regulation of cellular response to heat • protein transport • gene silencing by RNA • viral process • regulation of glucose transport • nuclear pore organization • NLS-bearing protein import into nucleus • intracellular transport of virus • tRNA export from nucleus • transmembrane transport • mRNA export from nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129401	69482
Ensembl	ENSG00000163002	ENSMUSG00000026999
UniProt	Q8NFH5	Q8R4R6
RefSeq (mRNA)	NM_001008544 NM_001287584 NM_001287585 NM_138285	NM_001190179 NM_027091
RefSeq (protein)	NP_001274513.1 NP_001274514.1 NP_612142.2	NP_001177108.1 NP_081367.1
Location (UCSC)	Chr 2: 183.12 – 183.16 Mb	Chr 2: 80.62 – 80.66 Mb
PubMed search	[1]	[2]
Wikidata

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Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.^[3]

Background

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: NUP35 nucleoporin 35kDa".

Further reading

• Rodenas E, Klerkx EP, Ayuso C, Audhya A, Askjaer P (2009). "Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly.". Developmental Biology. 327 (2): 399–409. doi:10.1016/j.ydbio.2008.12.024. PMID 19146848.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.