Nicotinate-nucleotide diphosphorylase (carboxylating)
| nicotinate-nucleotide diphosphorylase (carboxylating) | |||||||||
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Nicotinate-nucleotide pyrophosphorylase (carboxylating) hexamer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 2.4.2.19 | ||||||||
| CAS number | 37277-74-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19) is an enzyme that catalyzes the chemical reaction
- nicotinate D-ribonucleotide + diphosphate + CO2 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
The 3 substrates of this enzyme are nicotinate D-ribonucleotide, diphosphate, and CO2, whereas its two products are pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating). Other names in common use include quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD+ pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), and quinolinic phosphoribosyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1QAP, 1QPN, 1QPO, 1QPQ, 1QPR, 1X1O, 2B7N, 2B7P, and 2B7Q.
References
- GHOLSON RK, UEDA I, OGASAWARA N, HENDERSON LM (1964). "THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER". J. Biol. Chem. 239: 1208–14. PMID 14165928.
- Packman PM, Jakoby WB (1965). "Crystalline quinolinate phosphoribosyltransferase". J. Biol. Chem. 240 (10): 4107–8. PMID 5320648.