POLE4

POLE4
Identifiers
Aliases POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit
External IDs MGI: 1914229 HomoloGene: 41339 GeneCards: POLE4
Orthologs
Species Human Mouse
Entrez

56655

66979

Ensembl

ENSG00000115350

ENSMUSG00000030042

UniProt

Q9NR33

Q9CQ36

RefSeq (mRNA)

NM_019896

NM_025882

RefSeq (protein)

NP_063949.2

NP_080158.1

Location (UCSC) Chr 2: 74.96 – 74.97 Mb Chr 6: 82.62 – 82.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[3]

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[3]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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