Serralysin
| Serralysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.40 | ||||||||
| CAS number | 70851-98-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Serralysin (EC 3.4.24.40, Pseudomonas aeruginosa alkaline proteinase, Escherichia freundii proteinase, Serratia marcescens extracellular proteinase, Serratia marcescens metalloproteinase, Pseudomonas aeruginosa alk. protease, Serratia marcescens metalloprotease) is an enzyme.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction
- Preferential cleavage of bonds with hydrophobic residues in P1'
This extracellular endopeptidase is present in Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.
References
- ↑ Morihara, K.; Tsuzuki, H.; Oka, T. (1968). "Comparison of the specificities of various neutral proteinases from microorganisms". Arch. Biochem. Biophys. 123 (3): 572–588. doi:10.1016/0003-9861(68)90179-3. PMID 4967801.
- ↑ Morihara, K.; Tsuzuki, H.; Oka, T. (1973). "On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides". Biochim. Biophys. Acta. 309 (2): 414–429. doi:10.1016/0005-2744(73)90040-5. PMID 4199986.
- ↑ Nakajima, M.; Mizusawa, K.; Yoshida, F. (1974). "Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii". Eur. J. Biochem. 44 (1): 87–96. doi:10.1111/j.1432-1033.1974.tb03460.x. PMID 4212288.
- ↑ Decedue, C.J.; Broussard, E.A. II; L arson, A.D.; Braymer, H.D. (1979). "Purification and characterization of the extracellular proteinase of Serratia marcescens". Biochim. Biophys. Acta. 569 (2): 293–301. doi:10.1016/0005-2744(79)90065-2. PMID 383155.
- ↑ Doerr, M.; Traub, W.H. (1984). "Purification and characterization of two Serratia marcescens proteases". Zentralbl. Bakteriol., Mikrobiol. Hyg. Ser. A. 257 (1): 6–19. PMID 6380155.
- ↑ Nakahama, K.; Yoshimura, K.; Marumoto, R.; Kikuchi, M.; Lee, I.S.; Hase, T.; Matsubara, H. (1986). "Cloning and sequencing of Serratia protease gene". Nucleic Acids Res. 14: 5843–5856. doi:10.1093/nar/14.14.5843. PMC 311595
. PMID 3016665. - ↑ Dahler, G.S.; Barras, F.; Keen, N.T. (1990). "Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16". J. Bacteriol. 172 (10): 5803–5815. PMID 2211513.
- ↑ Okuda, K.; Morihara, K.; Atsumi, Y.; Takeuchi, H.; Kawamoto, S.; Kawasaki, H.; Suzuki, K.; Fukushima, J. (1990). "Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455". Infect. Immun. 58 (12): 4083–4088. PMID 2123832.
External links
- Serralysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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