Sterol esterase
| sterol esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.13 | ||||||||
| CAS number | 9026-00-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a sterol esterase (EC 3.1.1.13) is an enzyme that catalyzes the chemical reaction
- steryl ester + H2O sterol + fatty acid
Thus, the two substrates of this enzyme are steryl ester and H2O, whereas its two products are sterol and fatty acid.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is steryl-ester acylhydrolase. Other names in common use include cholesterol esterase, cholesteryl ester synthase, triterpenol esterase, cholesteryl esterase, cholesteryl ester hydrolase, sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile acid biosynthesis.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1AQL and 2BCE.
References
- Hyun J, Kothari H, Herm E, Mortenson J, Treadwell CR, Vahouny GV (1969). "Purification and properties of pancreatic juice cholesterol esterase". J. Biol. Chem. 244 (7): 1937–45. PMID 5780846.
- Okawa Y, Yamaguchi T. "Studies on sterol-ester hydrolase from Fusarium oxysporum. I Partial purification and properties". J. Tokyo. Biochem. (5): 1209–15. PMID 19426.
- Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal. Methods of Biochemical Analysis. 16: 219–72. doi:10.1002/9780470110348.ch4. ISBN 978-0-470-11034-8. PMID 4877146.
- Warnaar F (1987). "Triterpene ester synthesis in latex of Euphorbia species". Phytochemistry. 26 (10): 2715–2721. doi:10.1016/S0031-9422(00)83578-5.