TRNA-guanine15 transglycosylase

TRNA-guanine15 transglycosylase
Identifiers
EC number 2.4.2.48
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA-guanine15 transglycosylase (EC 2.4.2.48, tRNA transglycosylase, transfer ribonucleate glycosyltransferase, tRNA guanine15 transglycosidase, TGT, transfer ribonucleic acid guanine15 transglycosylase) is an enzyme with systematic name tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

guanine15 in tRNA + 7-cyano-7-carbaguanine 7-cyano-7-carbaguanine15 in tRNA + guanine

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15.

References

  1. Bai, Y.; Fox, D.T.; Lacy, J.A.; Van Lanen, S.G.; Iwata-Reuyl, D. (2000). "Hypermodification of tRNA in thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii". J. Biol. Chem. 275 (37): 28731–28738. doi:10.1074/jbc.M002174200. PMID 10862614.
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