CHRNA10

CHRNA10
Identifiers
Aliases	CHRNA10
External IDs	MGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10
Targeted by Drug
muscarine[1]
Gene ontology Molecular function • calcium channel activity • acetylcholine binding • acetylcholine receptor activity • acetylcholine-activated cation-selective channel activity • ion channel activity • receptor binding • extracellular ligand-gated ion channel activity Cellular component • integral component of membrane • acetylcholine-gated channel complex • perikaryon • postsynaptic membrane • membrane • plasma membrane • synapse • axon • cell junction Biological process • positive regulation of cytosolic calcium ion concentration • synaptic transmission, cholinergic • ion transport • detection of mechanical stimulus involved in sensory perception of sound • regulation of cell proliferation • calcium ion transmembrane transport • inner ear morphogenesis • transport • calcium ion transport • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57053	504186
Ensembl	ENSG00000129749	ENSMUSG00000066279
UniProt	Q9GZZ6	n/a
RefSeq (mRNA)	NM_001303034 NM_001303035 NM_020402	NM_001081424
RefSeq (protein)	NP_001289963.1 NP_001289964.1 NP_065135.2	n/a
Location (UCSC)	Chr 11: 3.67 – 3.67 Mb	Chr 7: 102.11 – 102.12 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein that in humans is encoded by the CHRNA10 gene.^[4] The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.^[5] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.^[6]

References

1. "Drugs that physically interact with Neuronal acetylcholine receptor subunit alpha-10 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics. 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119.
5. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337.
6. Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

External links

• CHRNA10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)