GRIN2C

GRIN2C
Identifiers
Aliases GRIN2C, GluN2C, NMDAR2C, NR2C, glutamate ionotropic receptor NMDA type subunit 2C
External IDs MGI: 95822 HomoloGene: 647 GeneCards: GRIN2C
Targeted by Drug
glycine, L-Aspartic Acid, homoquinolinic acid, Tetrazolylglycine, N-methyl-D-aspartic acid, 5,7-dichlorokynurenic acid, d-CCPene, selfotel, amantadine, dextromethorphan, dizocilpine, ketamine, levorphanol, phencyclidine[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

2905

14813

Ensembl

ENSG00000161509

ENSMUSG00000020734

UniProt

Q14957

Q01098

RefSeq (mRNA)

NM_000835
NM_001278553

NM_010350

RefSeq (protein)

NP_000826.2

NP_034480.2

Location (UCSC) Chr 17: 74.84 – 74.86 Mb Chr 11: 115.25 – 115.27 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene.[4][5]

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).[5]

Interactions

GRIN2C has been shown to interact with DLG4[6] and DLG3.[6]

See also

References

  1. ↑ "Drugs that physically interact with Glutamate receptor ionotropic, NMDA 2C view/edit references on wikidata".
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.
  5. 1 2 "Entrez Gene: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C".
  6. 1 2 Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.

Further reading

  • Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4-5): 683–8. PMID 9745929. 
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675. 
  • Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383. 
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905. 
  • Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237. 
  • Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S (1993). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochem. Biophys. Res. Commun. 197 (2): 922–6. doi:10.1006/bbrc.1993.2567. PMID 8267632. 
  • Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977. 
  • Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. 
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036. 
  • Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". NeuroReport. 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048. 
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1995). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1-2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747. 
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372. 
  • Dreyer EB, Lipton SA (1995). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955. 
  • Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L (1996). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056. 
  • Lin YJ, Bovetto S, Carver JM, Giordano T (1996). "Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery". Brain Res. Mol. Brain Res. 43 (1-2): 57–64. doi:10.1016/S0169-328X(96)00146-5. PMID 9037519. 
  • Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694. 
  • New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389. 
  • Daggett LP, Johnson EC, Varney MA, Lin FF, Hess SD, Deal CR, Jachec C, Lu CC, Kerner JA, Landwehrmeyer GB, Standaert DG, Young AB, Harpold MM, Veliçelebi G (1998). "The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression". J. Neurochem. 71 (5): 1953–68. doi:10.1046/j.1471-4159.1998.71051953.x. PMID 9798920. 

External links

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