GLRB

GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	MGI: 95751 HomoloGene: 20224 GeneCards: GLRB
Targeted by Drug
bilobalide, nifedipine, pregnenolone sulfate, picrotoxin[1]
Gene ontology Molecular function • glycine binding • protein binding • drug binding • extracellular-glycine-gated ion channel activity • chloride channel activity • extracellular ligand-gated ion channel activity • extracellular-glycine-gated chloride channel activity Cellular component • cytoplasm • integral component of membrane • postsynaptic membrane • cell projection • membrane • synapse • chloride channel complex • glycine-gated chloride channel complex • cell junction • dendrite • integral component of plasma membrane • plasma membrane Biological process • response to amino acid • startle response • protein heterooligomerization • regulation of membrane potential • gamma-aminobutyric acid receptor clustering • neurotransmitter-gated ion channel clustering • chloride transmembrane transport • nervous system development • acrosome reaction • ion transmembrane transport • neuromuscular process • transport • righting reflex • chloride transport • neuropeptide signaling pathway • visual perception • adult walking behavior • chemical synaptic transmission • ion transport • synaptic transmission, glycinergic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2743	14658
Ensembl	ENSG00000109738	ENSMUSG00000028020
UniProt	P48167	P48168
RefSeq (mRNA)	NM_000824 NM_001166060 NM_001166061	NM_001281969 NM_010298
RefSeq (protein)	NP_000815.1 NP_001159532.1 NP_001159533.1	NP_034428.2
Location (UCSC)	Chr 4: 157.08 – 157.17 Mb	Chr 3: 80.84 – 80.91 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.^[4][5][6]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]^[6]

See also

• Glycine receptor

References

1. "Drugs that physically interact with Glycine receptor subunit beta view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
5. Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
6. "Entrez Gene: GLRB glycine receptor, beta".

Further reading

• Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736.
• Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998.
• Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
• Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. PMID 14698963.
• Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304.
• Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848.

External links

• GLRB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.