GalNAc-alpha-(1-4)-GalNAc-alpha-(1-3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase

GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
Identifiers
EC number	2.4.1.292
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase (EC 2.4.1.292, PglH) is an enzyme with systematic name UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol $\rightleftharpoons$ 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol

This enzyme is solated from Campylobacter jejuni.

References

1. Glover, K.J.; Weerapana, E.; Imperiali, B. (2005). "In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation". Proc. Natl. Acad. Sci. USA. 102 (40): 14255–14259. Bibcode:2005PNAS..10214255G. doi:10.1073/pnas.0507311102. PMC 1242339. PMID 16186480.
2. Troutman, J.M.; Imperiali, B. (2009). "Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions". Biochemistry. 48 (12): 2807–2816. doi:10.1021/bi802284d. PMC 2736683. PMID 19159314.
3. Borud, B.; Viburiene, R.; Hartley, M.D.; Paulsen, B.S.; Egge-Jacobsen, W.; Imperiali, B.; Koomey, M. (2011). "Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system". Proc. Natl. Acad. Sci. USA. 108 (23): 9643–9648. Bibcode:2011PNAS..108.9643B. doi:10.1073/pnas.1103321108. PMC 3111294. PMID 21606362.

External links

• [//www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol+alpha-1,4-N-acetyl-D-galactosaminyltransferase GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase] at the US National Library of Medicine Medical Subject Headings (MeSH)