Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-b-N-acetylgalactosaminyltransferase
| Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.175 | ||||||||
| CAS number | 96189-40-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
This enzyme is involved in the biosynthesis of chondroitin sulfate.
References
- ↑ Rohrmann, K.; Niemann, R.; Buddecke, E. (1985). "Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate". Eur. J. Biochem. 148 (3): 463–469. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
- ↑ Kitagawa, H.; Uyama, T.; Sugahara, K. (2001). "Molecular cloning and expression of a human chondroitin synthase". J. Biol. Chem. 276: 38721–38726. doi:10.1074/jbc.M106871200. PMID 11514575.
- ↑ DeAngelis, P.L.; Padgett-McCue, A.J. (2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". J. Biol. Chem. 275: 24124–24129. doi:10.1074/jbc.M003385200. PMID 10818104.
- ↑ Ninomiya, T.; Sugiura, N.; Tawada, A.; Sugimoto, K.; Watanabe, H.; Kimata, K. (2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". J. Biol. Chem. 277: 21567–21575. doi:10.1074/jbc.M201719200. PMID 11943778.
External links
- Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)