Glycolipid 2-alpha-mannosyltransferase

glycolipid 2-alpha-mannosyltransferase
Identifiers
EC number 2.4.1.131
CAS number 74506-43-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a glycolipid 2-alpha-mannosyltransferase (EC 2.4.1.131) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to lipid-linked oligosaccharide, being attached by an alpha-1,2-D-mannosyl-D-mannose bond.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-oligosaccharide-lipid, mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, and oligosaccharide-lipid mannosyltransferase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1S4N, 1S4O, and 1S4P.

References


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