Integrin, beta 6

ITGB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UM8, 4UM9
Identifiers
Aliases	ITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
External IDs	MGI: 96615 HomoloGene: 685 GeneCards: ITGB6
Gene ontology Molecular function • integrin binding • virus receptor activity • receptor activity • protein binding Cellular component • integral component of membrane • integrin complex • receptor complex • plasma membrane • extracellular exosome • membrane • external side of plasma membrane • focal adhesion Biological process • integrin-mediated signaling pathway • viral entry into host cell • cell-matrix adhesion • inflammatory response • cell adhesion • extracellular matrix organization • viral process • cell adhesion mediated by integrin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3694	16420
Ensembl	ENSG00000115221	ENSMUSG00000026971
UniProt	P18564	Q9Z0T9
RefSeq (mRNA)	NM_000888 NM_001282353 NM_001282354 NM_001282355 NM_001282388 NM_001282389 NM_001282390	NM_001159564 NM_021359
RefSeq (protein)	NP_000879.2 NP_001269282.1 NP_001269284.1 NP_001269317.1	NP_001153036.1 NP_067334.1
Location (UCSC)	Chr 2: 160.1 – 160.27 Mb	Chr 2: 60.6 – 60.72 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.^[3][4][5]

Clinical effects

Mutations in ITGB6 cause amelogenesis imperfecta .^[6]

Interactions

Integrin, beta 6 has been shown to interact with FHL2.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173.
4. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem. 269 (9): 6940–8. PMID 8120056.
5. "Entrez Gene: ITGB6 integrin, beta 6".
6. Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
7. Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. UNITED STATES. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

Further reading

• Bowen JA, Hunt JS (2000). "The role of integrins in reproduction.". Proc. Soc. Exp. Biol. Med. 223 (4): 331–43. doi:10.1046/j.1525-1373.2000.22348.x. PMID 10721002.
• Jiang WM, Jenkins D, Yuan Q, et al. (1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.". Int. Immunol. 4 (9): 1031–40. doi:10.1093/intimm/4.9.1031. PMID 1382574.
• Busk M, Pytela R, Sheppard D (1992). "Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.". J. Biol. Chem. 267 (9): 5790–6. PMID 1532572.
• Sheppard D, Rozzo C, Starr L, et al. (1990). "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.". J. Biol. Chem. 265 (20): 11502–7. PMID 2365683.
• Weinacker A, Ferrando R, Elliott M, et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.". Am. J. Respir. Cell Mol. Biol. 12 (5): 547–56. doi:10.1165/ajrcmb.12.5.7537970. PMID 7537970.
• Huang XZ, Chen A, Agrez M, Sheppard D (1995). "A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.". Am. J. Respir. Cell Mol. Biol. 13 (2): 245–51. doi:10.1165/ajrcmb.13.2.7626292. PMID 7626292.
• Fernández-Ruiz E, Sánchez-Madrid F (1994). "Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31.". Genomics. 21 (3): 638–40. doi:10.1006/geno.1994.1325. PMID 7959743.
• Cone RI, Weinacker A, Chen A, Sheppard D (1994). "Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.". Cell Adhes. Commun. 2 (2): 101–13. doi:10.3109/15419069409004430. PMID 8081887.
• Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.". J. Biol. Chem. 271 (39): 24144–50. doi:10.1074/jbc.271.39.24144. PMID 8798654.
• Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.". Am. J. Physiol. 273 (1 Pt 1): L256–63. PMID 9252563.
• Ostergaard K, Salter DM, Petersen J, et al. (1998). "Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads.". Ann. Rheum. Dis. 57 (5): 303–8. doi:10.1136/ard.57.5.303. PMC 1752603. PMID 9741315.
• Munger JS, Huang X, Kawakatsu H, et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.". Cell. 96 (3): 319–28. doi:10.1016/S0092-8674(00)80545-0. PMID 10025398.
• Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
• Arihiro K, Kaneko M, Fujii S, et al. (2000). "Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma.". Breast Cancer. 7 (1): 19–26. doi:10.1007/bf02967183. PMID 11029766.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Arend LJ, Smart AM, Briggs JP (2001). "Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development.". J. Am. Soc. Nephrol. 11 (12): 2297–305. PMID 11095652.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

External links

• GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia
• ITGB6 Info with links in the Cell Migration Gateway