JNJ-5207852

JNJ-5207852

Names
Preferred IUPAC name 1-{3-[4-(Piperidin-1-ylmethyl)phenoxy]propyl}piperidine
Systematic IUPAC name 1-({4-[3-(Piperidin-1-yl)propoxy]phenyl}methyl)piperidine
Identifiers
3D model (Jmol)	Interactive image Interactive image
Abbreviations	JNJ-5207852
ChEBI	CHEBI:312531
ChEMBL	ChEMBL129542
ChemSpider	2046959
IUPHAR/BPS	1256
MeSH	JNJ-5207852
PubChem	2766326
InChI InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2 Key: PTKHFRNHJULJKT-UHFFFAOYSA-N
SMILES O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3 O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3
Properties
Chemical formula	C20H32N2O
Molar mass	316.480 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

JNJ-5207852 is a histamine antagonist selective for the H₃ subtype. It has stimulant and nootropic effects in animal studies,^[1] and has been suggested as a possible treatment for memory defects associated with epilepsy.^[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 is currently in Phase II clinical trials for the treatment of narcolepsy.^[3]

References

1. Barbier AJ, Berridge C, Dugovic C, et al. (November 2004). "Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist". Br. J. Pharmacol. 143 (5): 649–61. doi:10.1038/sj.bjp.0705964. PMC 1575430. PMID 15466448.
2. Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K. Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology. 2006 Mar;50(4):404-11. PMID 16310812
3. Esbenshade TA, Browman KE, Bitner RS, Strakhova M, Cowart MD, Brioni JD (July 2008). "The histamine H3 receptor: an attractive target for the treatment of cognitive disorders". Br. J. Pharmacol. 154 (6): 1166–81. doi:10.1038/bjp.2008.147. PMC 2483387. PMID 18469850.