Antazoline

Antazoline

Clinical data
Trade names	Vasocon-a
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical (nasal, eye drops)
ATC code	R01AC04 (WHO) R06AX05 (WHO)
Identifiers
IUPAC name N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
CAS Number	91-75-8
PubChem (CID)	2200
IUPHAR/BPS	7116
DrugBank	DB08799
ChemSpider	2115
UNII	DHA8014SS1
KEGG	D07458
ChEBI	CHEBI:84115
ChEMBL	CHEMBL1305
Chemical and physical data
Formula	C17H19N3
Molar mass	265.353 g/mol
3D model (Jmol)	Interactive image
SMILES N\1=C(\NCC/1)CN(c2ccccc2)Cc3ccccc3
InChI InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19) Key:REYFJDPCWQRWAA-UHFFFAOYSA-N
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Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.^[1] The drug is a Histamine H1 receptor antagonist:^[2] selectively binding to but not activating the receptor, therby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

References

1. Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. PMID 7425039.
2. Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako. "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f.