Chromic acid

Chromic acid

Names
IUPAC name Chromic acid
Systematic IUPAC name Dihydroxidodioxidochromium
Other names Chromic(VI) acid Tetraoxochromic acid
Identifiers
CAS Number	7738-94-5
3D model (Jmol)	Interactive image Interactive image
ChEBI	CHEBI:33143
ChemSpider	22834
ECHA InfoCard	100.028.910
EC Number	231-801-5
Gmelin Reference	25982
PubChem	24425
UNII	SA8VOV0V7Q
InChI InChI=1S/Cr.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2 Key: KRVSOGSZCMJSLX-UHFFFAOYSA-L InChI=1/Cr.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2/rCrH2O4/c2-1(3,4)5/h2-3H Key: KRVSOGSZCMJSLX-OOUCQFSRAZ
SMILES O[Cr](O)(=O)=O O=[Cr](=O)(O)O
Properties
Chemical formula	CrH2O4
Molar mass	118.01 g·mol^−1
Appearance	Dark red crystals
Density	1.201 g cm^−3
Melting point	197 °C (387 °F; 470 K)
Boiling point	250 °C (482 °F; 523 K) (decomposes)
Solubility in water	169 g/100 mL
Acidity (pKa)	-0.8 to 1.6
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose)	51.9 mg/kg (H2CrO4·2Na, rat, oral)[1]
US health exposure limits (NIOSH):
PEL (Permissible)	TWA 0.005 mg/m^3[2]
REL (Recommended)	TWA 0.001 mg Cr(VI)/m^3[2]
IDLH (Immediate danger)	15 mg Cr(VI)/m^3[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

The term chromic acid is usually used for a mixture made by adding concentrated sulfuric acid to a dichromate, which may contain a variety of compounds, including solid chromium trioxide. This kind of chromic acid may be used as a cleaning mixture for glass. Chromic acid may also refer to the molecular species, H₂CrO₄ of which the trioxide is the anhydride. Chromic acid features chromium in an oxidation state of +6 (or VI). It is a strong and corrosive oxidising agent.

Molecular chromic acid

Partial predominance diagram for chromate

Molecular chromic acid, H₂CrO₄, has much in common with sulfuric acid, H₂SO₄. Both are classified as strong acids, though only the first proton is lost easily.

H₂CrO₄ ⇌ [HCrO₄]⁻ + H⁺

The pK_a for the equilibrium is not well characterized. Reported values vary between about −0.8 to 1.6.^[3] The value at zero ionic strength is difficult to determine because half dissociation only occurs in very acidic solution, at about pH 0, that is, with an acid concentration of about 1 mol dm⁻³. A further complication is that the ion [HCrO₄]⁻ has a marked tendency to dimerize, with the loss of a water molecule, to form the dichromate ion, [Cr₂O₇]²⁻:

2 [HCrO₄]⁻ ⇌ [Cr₂O₇]²⁻ + H₂O      log K_D = 2.05.

Furthermore, the dichromate can be protonated:

[HCr₂O₇]⁻ ⇌ [Cr₂O₇]²⁻ + H⁺      pK = 1.8^[4]

The pK value for this reaction shows that it can be ignored at pH > 4.

Loss of the second proton occurs in the pH range 4–8, making the ion [HCrO₄]⁻ a weak acid.

Molecular chromic acid could in principle be made by adding chromium trioxide to water (cf. manufacture of sulfuric acid).

CrO₃ + H₂O ⇌ H₂CrO₄

but in practice the reverse reaction occurs when molecular chromic acid is dehydrated. This is what happens when concentrated sulfuric acid is added to a dichromate solution. At first the colour changes from orange (dichromate) to red (chromic acid) and then deep red crystals of chromium trioxide precipitate from the mixture, without further colour change. The colours are due to LMCT transitions.

Chromium trioxide is the anhydride of molecular chromic acid. It is a Lewis acid and can react with a Lewis base, such as pyridine in a non-aqueous medium such as dichloromethane (Collins reagent).

Dichromic acid

Dichromic acid, H₂Cr₂O₇, (structure illustrated top right) is the fully protonated form of the dichromate ion and also can be seen as the product of adding chromium trioxide to molecular chromic acid.

[Cr₂O₇]²⁻ + 2H⁺ ⇌ H₂Cr₂O₇ ⇌ H₂CrO₄ + CrO₃

It is probably present in chromic acid cleaning mixtures along with the mixed chromosulfuric acid H₂CrSO₇.

Uses

Chromic acid is an intermediate in chromium plating, and is also used in ceramic glazes, and colored glass. Because a solution of chromic acid in sulfuric acid (also known as a sulfochromic mixture or chromosulfuric acid) is a powerful oxidizing agent, it can be used to clean laboratory glassware, particularly of otherwise insoluble organic residues. This application has declined due to environmental concerns.^[5] Furthermore, the acid leaves trace amounts of paramagnetic chromic ions — Cr(III) — that can interfere with certain applications, such as NMR spectroscopy. This is especially the case for NMR tubes.^[6]

Chromic acid was widely used in the instrument repair industry, due to its ability to "brighten" raw brass. A chromic acid dip leaves behind a bright yellow patina on the brass. Due to growing health and environmental concerns, many have discontinued use of this chemical in their repair shops.

It was used in hair dye in the 1940s, under the name Melereon.^[7]

As a bleach in black and white photographic reversal processing.^[8]

Reactions

Chromic acid is capable of oxidizing many kinds of organic compounds and many variations on this reagent have been developed:

• Chromic acid in aqueous sulfuric acid and acetone is known as the Jones reagent, which will oxidize primary and secondary alcohols to carboxylic acids and ketones respectively, while rarely affecting unsaturated bonds.^[9]
• Pyridinium chlorochromate is generated from chromium trioxide and pyridinium chloride. This reagent converts primary alcohols to the corresponding aldehydes (R–CHO).^[9]
• Collins reagent is an adduct of chromium trioxide and pyridine used for diverse oxidations.
• Chromyl chloride, CrO₂Cl₂ is a well-defined molecular compound that is generated from chromic acid.

Illustrative transformations

• Oxidation of methylbenzenes to benzoic acids.^[10]
• Oxidative scission of indene to homophthalic acid.^[11]
• Oxidation of secondary alcohol to ketone (cyclooctanone)^[12] and nortricyclanone.^[13]

Use in qualitative organic analysis

In organic chemistry, dilute solutions of chromic acid can be used to oxidize primary or secondary alcohols to the corresponding aldehydes and ketones. Tertiary alcohol groups are unaffected. Because of the oxidation is signaled by a color change from orange to a blue-green, chromic acid is used as a qualitative analytical test for the presence of primary or secondary alcohols.^[9]

Alternative reagents

In oxidations of alcohols or aldehydes into carboxylic acids, chromic acid is one of several reagents, including several that are catalytic. For example, nickel(II) salts catalyze oxidations by bleach (hypochlorite).^[14] Aldehydes are relatively easily oxidised to carboxylic acids, and mild oxidising agents are sufficient. Silver(I) compounds have been used for this purpose. Each oxidant offers advantages and disadvantages. Instead of using chemical oxidants, electrochemical oxidation is often possible.

Safety

Hexavalent chromium compounds (including chromium trioxide, chromic acids, chromates, chlorochromates) are toxic and carcinogenic. For this reason, chromic acid oxidation is not used on an industrial scale except in the aerospace industry.

Chromium trioxide and chromic acids are strong oxidisers and may react violently if mixed with easily oxidisable organic substances. Fires or explosions may result.

Chromic acid burns are treated with a dilute Sodium thiosulfate solution.^[15]

Notes

1. "Chromic acid and chromates". Immediately Dangerous to Life and Health. National Institute for Occupational Safety and Health (NIOSH).
2. "NIOSH Pocket Guide to Chemical Hazards #0138". National Institute for Occupational Safety and Health (NIOSH).
3. IUPAC SC-Database A comprehensive database of published data on equilibrium constants of metal complexes and ligands
4. Brito, F.; Ascanioa, J.; Mateoa, S.; Hernándeza, C.; Araujoa, L.; Gili, P.; Martín-Zarzab, P.; Domínguez, S.; Mederos, A. (1997). "Equilibria of chromate(VI) species in acid medium and ab initio studies of these species". Polyhedron. 16 (21): 3835–3846. doi:10.1016/S0277-5387(97)00128-9.
5. J. M. McCormick (2006-06-30). "Cleaning Glassware". Truman State University.
6. "NMR-010: Proper Cleaning Procedures for NMR Sample Tubes". Wilmad. Retrieved 2008-06-27.
7. "Watson v Buckley, Osborne, Garrett & Co Ltd and Wyrovoys Products Ltd [1940] 1 All ER 174".
8. "Fomapan R" (PDF). Fomapan R. Foma. Retrieved 6 April 2016.
9. Freeman, F. "Chromic Acid" Encyclopedia of Reagents for Organic Synthesis (2001) John Wiley & Sons, doi:10.1002/047084289X.rc164
10. Kamm O.; Matthews, A. O. (1941). "p-Nitrobenzoic Acid". Org. Synth.; Coll. Vol., 1, p. 392
11. Grummitt, O.; Egan, R.; Buck, A. "Homophthalic Acid and Anhydride". Org. Synth.; Coll. Vol., 3, pp. 449 (1955
12. Eisenbraun, E. J. "Cyclooctanone". Org. Synth.; Coll. Vol., 5, pp. 310 (1973
13. Meinwald, J.; Crandall, J.; Hymans W. E. "Nortricyclanone". Org. Synth.; Coll. Vol., 5, p. 866
14. J. M. Grill; J. W. Ogle; S. A. Miller (2006). "An Efficient and Practical System for the Catalytic Oxidation of Alcohols, Aldehydes, and α,β-Unsaturated Carboxylic Acids". J. Org. Chem. 71 (25): 9291–9296. doi:10.1021/jo0612574. PMID 17137354.
15. Hettiaratchy, Shehan; Dziewulski, Peter (2004-06-12). "Pathophysiology and types of burns". BMJ: British Medical Journal. 328 (7453): 1427–1429. doi:10.1136/bmj.328.7453.1427. ISSN 0959-8138. PMC 421790. PMID 15191982.

References

• Alcohols from Carbonyl Compounds: Oxidation-Reduction and Organometallic Compounds (PDF)

External links

• International Chemical Safety Card 1194
• "NIOSH Pocket Guide to Chemical Hazards #0138". National Institute for Occupational Safety and Health (NIOSH).
• IARC Monograph "Chromium and Chromium compounds"