MAP3K9

MAP3K9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DTC, 4UY9
Identifiers
Aliases	MAP3K9, MEKK9, MLK1, PRKE1, mitogen-activated protein kinase kinase kinase 9
External IDs	MGI: 2449952 HomoloGene: 76377 GeneCards: MAP3K9
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • JUN kinase kinase kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • MAP kinase kinase kinase activity • MAP kinase kinase activity Cellular component • cellular component • intracellular Biological process • regulation of transcription, DNA-templated • activation of JUN kinase activity • phosphorylation • activation of MAPKK activity • cell death • transcription, DNA-templated • protein phosphorylation • positive regulation of apoptotic process • protein autophosphorylation • apoptotic process • activation of JNKK activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4293	338372
Ensembl	ENSG00000006432	ENSMUSG00000042724
UniProt	P80192	Q3U1V8
RefSeq (mRNA)	NM_001284230 NM_001284231 NM_001284232 NM_033141	NM_001174107 NM_177395
RefSeq (protein)	NP_001271159.1 NP_149132.2	NP_001167578.1 NP_796369.2
Location (UCSC)	Chr 14: 70.72 – 70.81 Mb	Chr 12: 81.71 – 81.78 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: MAP3K9 mitogen-activated protein kinase kinase kinase 9".

Further reading

• Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.
• Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.". Eur. J. Biochem. 213 (2): 701–10. doi:10.1111/j.1432-1033.1993.tb17810.x. PMID 8477742.
• Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.". Eur. J. Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
• Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.". Mol. Cell. Biol. 21 (14): 4713–24. doi:10.1128/MCB.21.14.4713-4724.2001. PMC 87148. PMID 11416147.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.". Biochemistry. 43 (51): 16348–55. doi:10.1021/bi049866y. PMID 15610029.