SNF1LK

SIK1
Identifiers
Aliases	SIK1, MSK, SIK, SNF1LK, EIEE30, salt inducible kinase 1
External IDs	HomoloGene: 136094 GeneCards: SIK1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cAMP response element binding protein binding • 14-3-3 protein binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding • magnesium ion binding Cellular component • cytoplasm • nucleus Biological process • regulation of myotube differentiation • cell differentiation • intracellular signal transduction • phosphorylation • regulation of sodium ion transport • rhythmic process • cardiac muscle cell differentiation • negative regulation of triglyceride biosynthetic process • negative regulation of CREB transcription factor activity • multicellular organism development • protein phosphorylation • negative regulation of gluconeogenesis • regulation of mitotic cell cycle • regulation of cell differentiation • protein autophosphorylation • cell cycle • positive regulation of anoikis • entrainment of circadian clock by photoperiod • cellular response to hormone stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	150094	n/a
Ensembl	ENSG00000142178	n/a
UniProt	P57059	n/a
RefSeq (mRNA)	NM_173354	n/a
RefSeq (protein)	NP_775490.2 NP_001307572.1	n/a
Location (UCSC)	Chr 21: 43.41 – 43.43 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.^[2][3]

References

1. "Human PubMed Reference:".
2. Ruiz JC, Conlon FL, Robertson EJ (Apr 1995). "Identification of novel protein kinases expressed in the myocardium of the developing mouse heart". Mech Dev. 48 (3): 153–64. doi:10.1016/0925-4773(94)90056-6. PMID 7893599.
3. "Entrez Gene: SNF1LK SNF1-like kinase".

Further reading

• Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
• Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.